Results 41 to 50 of about 6,049 (169)

Health Care Use Among Patients Presenting to Emergency Department for Gout Flares in Ontario, Canada: A Population‐Based Health Systems Analysis

Arthritis Care &Research, EarlyView.
Objective We characterized emergency department (ED) gout visits and identified patient characteristics and health services patterns contributing to ED presentations. Methods We conducted a population‐based study of ED gout visits in Ontario, Canada, between 2014 and 2023.
Timothy S. H. Kwok, Samantha Morais, William K. Silverstein, Clare L. Atzema, Gregory Choy, Priyanka Chandratre, Ping Li, Jessica Widdifield   +7 more
wiley   +1 more source

Cardiovascular outcomes of febuxostat and allopurinol: A long-term Taiwanese nationwide cohort study

Journal of the Formosan Medical Association
Introduction: Studies with larger cohorts and longer follow-up periods are required for cardiovascular safety of febuxostat and allopurinol. Material and methods: This population-based, retrospective study was conducted with the Taiwan National Health ...
Tsung-Lin Yang, Hsin-Bang Leu, Shing-Jong Lin, Jiun-Lin Horng, Chun-Ming Shih   +4 more
doaj   +1 more source

Urate-lowering therapy for CKD patients with asymptomatic hyperuricemia without proteinuria elucidated by attribute-based research in the FEATHER Study

Scientific Reports, 2022
Attribute-based medicine is essential for patient-centered medicine. To date, the groups of patients with chronic kidney disease (CKD) requiring urate-lowering therapy are clinically unknown.
Hiroshi Kataoka, Toshio Mochizuki, Mamiko Ohara, Yuki Tsuruta, Naomi Iwasa, Rie Yoshida, Ken Tsuchiya, Kosaku Nitta, Kenjiro Kimura, Tatsuo Hosoya, the FEATHER Investigators   +10 more
doaj   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source

Febuxostat ameliorates EAE.

, 2013
Febuxostat (0.75 mg/kg) or vehicle (water) was administered via water bottle from day 10 post-immunization until the end of the study. (A) Mean clinical scores of control mice (filled circle; n = 7) and febuxostat-treated mice (open square; n = 6) after ...
Hideki Mochizuki (204792), Josephe Archie Honorat (443304), Harutoshi Fujimura (178038), Takashi Shirakura (443305), Satoru Tada (439307), Yuji Nakatsuji (339577), Makoto Kinoshita (2566), Kazushiro Takata (339569), Toru Koda (439309), Saburo Sakoda (339576), Tatsusada Okuno (339570)   +10 more
core   +1 more source

Photochemical Reaction Discovery Enabled by the Dynamic Speciation of Copper Complexes

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A strategy for accelerated photochemical reaction discovery is reported that harnesses the dynamic speciation of copper complexes, driven by their labile metal–ligand bonds. This platform simplifies reaction screening by combining an earth‐abundant copper(II) salt with commercially available ligands, which reversibly generate multiple catalytic species
Alessio Regni, Siyu Liang, Supreeta Sen, Hailey Hendricks, Xijue Wu, Matthew V. Pecoraro, Jose B. Roque   +6 more
wiley   +2 more sources

Switching from allopurinol to febuxostat: efficacy and safety in the treatment of hyperuricemia in renal transplant recipients

Renal Failure, 2019
The aim of this study was to evaluate the efficacy and tolerability of febuxostat in renal transplant recipients who were previously treated with allopurinol (the daily oral dose is 100 mg).
Yanchun Li, Min Liu, Xuelei Zhang, Yuewu Lu, Juan Meng   +4 more
doaj   +1 more source

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

Impact of febuxostat on visit-to-visit blood pressure variability: insights from the randomised PRIZE Study

RMD Open, 2022
Objectives Although uric acid lowering therapies, including xanthine oxidase (XO) inhibition, may reduce the absolute level of blood pressure (BP), the effect of XO inhibition on BP variability is largely unknown.
Yoshio Kobayashi, Atsushi Tanaka, Yuichi Saito, Daigaku Uchida, Koichi Node, Naoto Yokota, Hisako Yoshida, Yuji Koide, Kazuo Matsunaga, Chikara Ueyama   +9 more
doaj   +1 more source

Pharmacokinetics and Bioequivalence of Two Formulations of Febuxostat 40-Mg and 80-Mg Tablets: A Randomized, Open-Label, 4-Way Crossover Study in Healthy Chinese Male Volunteers.

PLoS ONE, 2016
UnlabelledThe present study aimed to investigate the pharmacokinetic properties of febuxostat in healthy Chinese male volunteers and evaluate whether the two formulations of febuxostat 40-mg and 80-mg tablets are bioequivalent.
Zhu Luo, Feng Nan, Jia Miao, Zhihui Chen, Mei Li, Maozhi Liang   +5 more
doaj   +1 more source