Results 121 to 130 of about 180,670 (278)

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

The fecal microbiome in dogs with acute diarrhea and idiopathic inflammatory bowel disease. [PDF]

, 2012
Recent molecular studies have revealed a highly complex bacterial assembly in the canine intestinal tract. There is mounting evidence that microbes play an important role in the pathogenesis of acute and chronic enteropathies of dogs, including ...
Toresson, Linda, Jörg M. Steiner (107366), Ivan Ivanov, Dillman, Enricka M., Enricka M Dillman, Ivanov, Ivan, Stefan Unterer (107353), Heimesaat, Markus M., García Mazcorro, José Francisco, Jan S. Suchodolski (107343), Romy M Heilmann, Markel, Melissa E., Enricka M. Dillman (107363), Linda Toresson (107370), Melissa E Markel, Markel, Melissa, Linda Toresson, Steiner, J��rg M., Audrey K. Cook (107368), Cook, Audrey K., Jan S Suchodolski, Minamoto, Yasushi, Jörg M Steiner, Garcia-Mazcorro, Jose F., Priyanka Kachroo, Scot E. Dowd (107356), Heilmann, Romy M., Dowd, Scot E., Yasushi Minamoto, Jose F. Garcia-Mazcorro (107351), Unterer, Stefan, Romy M. Heilmann (107355), Jose F Garcia-Mazcorro, Stefan Unterer, Yasushi Minamoto (107360), Scot E Dowd, Audrey K Cook, Ivan Ivanov (107359), Melissa E. Markel (107347), Priyanka Kachroo (107357), Kachroo, Priyanka, Steiner, Jörg M., Suchodolski, Jan S.   +42 more
core   +2 more sources

Fecal microbiota transplantation: Is there a role in the eradication of carbapenem-resistant Klebsiella pneumoniae intestinal carriage?

Revista Española de Enfermedades Digestivas, 2017
The authors present the case of a 66-year-old woman with four hospitalizations due to recurrent Clostridium difficile infection (CDI) non responsive to vancomycin and fidaxomicin. Furthermore, intestinal colonization with carbapenem-resistant Klebsiella pneumoniae (CRKP) was identified after a positive stool culture in a screening routinely performed ...
Ponte,Ana, Pinho,Rolando, Mota,Margarida
openaire   +2 more sources

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Fecal carriage and molecular epidemiology of carbapenem-resistant Enterobacteriaceae from outpatient children in Shanghai

BMC Infectious Diseases, 2019
Fecal colonization with carbapenem-resistant Enterobacteriaceae (CRE) is a risk factor for bacterial translocation resulting in subsequent endogenous infections. The purpose of this study is to investigate the prevalence of CRE strains colonization in stool samples of outpatient in a tertiary pediatric hospital of Shanghai, China.In a retrospective ...
Fen Pan, Dongxing Tian, Bingjie Wang, Wantong Zhao, Huihong Qin, Tiandong Zhang, Hong Zhang   +6 more
openaire   +3 more sources

Sunscreen‐Inspired Nano‐Pesticide for UV‐Shielding and Laccase‐Responsive Delivery of Mancozeb With Enhanced Fungicidal Efficacy and Ecological Safety

Advanced Science, EarlyView.
The sunscreen‐inspired nano‐pesticide, MCB@URFSL, provides UV‐shielding, enhanced rainfastness, and laccase‐responsive delivery for improved fungicidal efficacy and high ecological safety. ABSTRACT Fungicides are a crucial tool for protecting crops and ensuring consistent food supply.
Jin Yan, Xin Ye, Linping He, Cheng Hong, Xu‐Huan Zhao, Gizachew Mulugeta Manahelohe, Xiao‐Tong Feng, Yu‐Cheng Gu, Qiang Bian, Min Wu, Ming‐Zhi Zhang   +10 more
wiley   +1 more source

Subjective skeletal discomfort measured using a comfort questionnaire following a load carriage exercise [PDF]

, 2009
Objective: Limited research has been conducted into the effect of load carriage on discomfort and injuries. This study aimed to determine the skeletal discomfort for part-time soldiers who completed a 1-hour field march carrying 24 kg.
Haslam, Roger, Birrell, Stewart A.
core  

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Can load carriage system weight, design and placement affect pain and discomfort? A systematic review [PDF]

, 2011
Purpose: A systematic review of the literature was conducted to answer the following questions: 1. Does usage or weight of load carriage system cause pain, perceived exertion or discomfort? 2.
Golriz, S., Walker, B.
core  

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source