Results 91 to 100 of about 308,893 (299)

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Skin microbiome modulation induced by probiotic solutions

, 2019
Background: The skin is colonized by a large number of microorganisms, most of which are beneficial or harmless. However, disease states of skin have specific microbiome compositions that are different from those of healthy skin.
Pereira de Lima, Joao, Brüggemann, Holger, Paetzold, Bernhard, 1981-, Knödlseder, Nastassia, Willis, Jesse R., Quist, Sven Roy, Gabaldón Estevan, Juan Antonio, 1973-, Güell Cargol, Marc, 1982-   +7 more
core   +1 more source

Establishment of normal gut microbiota is compromised under excessive hygiene conditions [PDF]

, 2011
Peer ...
Stokes, C.R., Schmidt, B, Gill, B.P., Schmidt, B., John R Pluske, Imke E. Mulder, Lewis, M, Kelly, D., Aminov, Rustam, Bhupinder P Gill, Gill, Bhupinder P, Bailey, Mick, Musk, Corran C, Pluske John R., Aminov, Rustam I, Bailey, M., Lewis Marie, Mick Bailey, Musk Corran C., Bailey Mick, Rustam I. Aminov, Stokes, CR, Stokes, Christopher, Musk, Corran, Marie Lewis, Mulder Imke E., Rustam I Aminov, Christopher R Stokes, Kelly, Denise, Pluske, JR, Mulder, Imke E, Stokes, Christopher R, Aminov, R I, Mulder, Imke, Bettina Schmidt, Stokes Christopher R., John R. Pluske, Christopher R. Stokes, Prosser, James I, Plusk, John, Musk C, C, Prosser, James, Gill Bhupinder P., Gill, Bhupinder, Kelly Denise, Lewis, Marie, Bailey, M, Musk, C.C., Lewis, M., Schmidt Bettina, Mulder, I E, Pluske, John R, Mulder, I.E., Prosser, JI, Aminov, R.I., James I Prosser, Pluske, J.R., Kelly, D, Corran C Musk, Imke E Mulder, Prosser James I., Corran C. Musk, Gill, BP, Schmidt, Bettina, James I. Prosser, Aminov Rustam I., Bhupinder P. Gill, Prosser, J.I., Denise Kelly   +68 more
core   +1 more source

Microbiome composition of Anna's hummingbirds differs among regions of the gastrointestinal tract

Journal of Avian Biology, 2022
The gastrointestinal (GI) microbiome is an important mediator and indicator of host physiology, health and fitness in many vertebrate systems, but sources of variation in microbiome composition within species are poorly understood, particularly in free ...
Rachel Dutch, Lisa A. Tell, Ruta Bandivadekar, Rachel L. Vannette   +3 more
doaj   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Fecal and Salivary Cortisol Concentrations in Woolly (Lagothrix ssp.) and Spider Monkeys (Ateles spp.) [PDF]

, 2009
Detrimental physiological effects due to stressors can contribute to the low captive success of primates. The objective of this research was to investigate the potential impact of diet composition on cortisol concentrations in feces and saliva in woolly (
Heugten, E., van, Scott Whisnant, van Heugten, E., Whisnant, S., Swarts, H.J.M., Kimberly D. Ange-van Heugten, Ange-van Heugten, K.D., Peter Ferket, Saskia Timmer, Abahor Elias, Timmer, S., Bosch, G., Verstegen, M.W.A., Martin W. A. Verstegen, Guido Bosch, Elias, A., Hans J. M. Swarts, Eric van Heugten, Ferket, P.   +18 more
core   +1 more source