Results 151 to 160 of about 749,609 (349)

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Therapeutic methods of gut microbiota modification in colorectal cancer management – fecal microbiota transplantation, prebiotics, probiotics, and synbiotics

Gut Microbes, 2020
The link between gut microbiota and the development of colorectal cancer has been investigated. An imbalance in the gut microbiota promotes the progress of colorectal carcinogenesis via multiple mechanisms, including inflammation, activation of ...
Karolina Kaźmierczak-Siedlecka, Agnieszka Daca, Mateusz Fic, Thierry van de Wetering, Marcin Folwarski, Wojciech Makarewicz   +5 more
doaj   +1 more source

Establishment of normal gut microbiota is compromised under excessive hygiene conditions [PDF]

, 2011
Peer ...
Stokes, C.R., Schmidt, B, Gill, B.P., Schmidt, B., John R Pluske, Imke E. Mulder, Lewis, M, Kelly, D., Aminov, Rustam, Bhupinder P Gill, Gill, Bhupinder P, Bailey, Mick, Musk, Corran C, Pluske John R., Aminov, Rustam I, Bailey, M., Lewis Marie, Mick Bailey, Musk Corran C., Bailey Mick, Rustam I. Aminov, Stokes, CR, Stokes, Christopher, Musk, Corran, Marie Lewis, Mulder Imke E., Rustam I Aminov, Christopher R Stokes, Kelly, Denise, Pluske, JR, Mulder, Imke E, Stokes, Christopher R, Aminov, R I, Mulder, Imke, Bettina Schmidt, Stokes Christopher R., John R. Pluske, Christopher R. Stokes, Prosser, James I, Plusk, John, Musk C, C, Prosser, James, Gill Bhupinder P., Gill, Bhupinder, Kelly Denise, Lewis, Marie, Bailey, M, Musk, C.C., Lewis, M., Schmidt Bettina, Mulder, I E, Pluske, John R, Mulder, I.E., Prosser, JI, Aminov, R.I., James I Prosser, Pluske, J.R., Kelly, D, Corran C Musk, Imke E Mulder, Prosser James I., Corran C. Musk, Gill, BP, Schmidt, Bettina, James I. Prosser, Aminov Rustam I., Bhupinder P. Gill, Prosser, J.I., Denise Kelly   +68 more
core   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Altered fecal microbiota composition in patients with major depressive disorder.

Brain, behavior, and immunity, 2015
Studies using animal models have shown that depression affects the stability of the microbiota, but the actual structure and composition in patients with major depressive disorder (MDD) are not well understood.
Haiyin Jiang, Zong-Xin Ling, Yonghua Zhang, Hong-Jing Mao, Zhanping Ma, Yan Yin, Wei-Hong Wang, Wen-Xin Tang, Zhonglin Tan, Jianfei Shi, Lanjuan Li, B. Ruan   +11 more
semanticscholar   +1 more source

Fecal Microbiota Transplantation Alleviated Paclitaxel-Induced Peripheral Neuropathy by Interfering with Astrocytes and TLR4/p38MAPK Pathway in Rats

, 2023
Haibin Shi,1 Minmin Chen,2 Caihong Zheng,2 Bian Yinglin,2 Bin Zhu2 1Department of Anesthesiology, the Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Department of ...
Yinglin B, Chen M, Zheng C, Zhu B, Shi H
core