Results 191 to 200 of about 30,050 (254)

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, Volume 13, Issue 33, 15 June 2026.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, Volume 13, Issue 31, 4 June 2026.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Validation of an Automated Fluorescence‐ and Image‐Based Viable Cell Counting Method for Fecal Microbiota Transplantation Drug Products

Biotechnology Journal, Volume 21, Issue 6, June 2026.
Graphical Abstract and Lay Summary This study presents the first systematic development and analytical validation of an automated fluorescence‐ and image‐based viable‐cell counting method for fecal microbiota transplantation (FMT) drug products in accordance with ICH Q2(R2).
Timon Lang, Fedja Farowski, Jozef Al‐Gousous, Peter Langguth, Maria J. G. T. Vehreschild   +4 more
wiley   +1 more source

Fecal Microbiota Transplantation From Healthy Donors Reduces Glycemic Variability in Streptozotocin-Induced Diabetic Rats via Enhanced Hepatic Glycogen Synthesis. [PDF]

Int J Endocrinol
Dou M, Xu J, Ye X, Liu J, Shi L.
europepmc   +1 more source

Gut Microbiome–Sleep Crosstalk: Mechanistic Pathways, Dysbiosis Signatures, and Microbiome‐Based Interventions

Brain and Behavior, Volume 16, Issue 6, June 2026.
Gut dysbiosis and sleep disturbances interact bidirectionally through microbial metabolites, immune activation, and neuroendocrine signaling along the gut–brain axis. Microbiome‐based interventions, including probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation, may help improve sleep quality and reduce inflammatory ...
Ghaleb Oriquat, Shaker Al‐Hasnaawei, Hayjaa Mohaisen Mousa, Malathi H, Siya Singla, Samir Sahoo, Vimal Arora, Ashish Singh Chauhan, Mehrdad Nourizadeh   +8 more
wiley   +1 more source

Fecal Microbiota Transplantation From Patients With Social Anxiety Disorder Is Associated With General Anxiety‐Like Behavior and Gut Microbiota Alterations in Mice

Brain and Behavior, Volume 16, Issue 6, June 2026.
Fecal microbiota transplantation from patients with social anxiety disorder (SAD) into mice induces anxiety‐like behaviors, accompanied by gut microbiota alterations (increased Bacteroidota, decreased butyrate producers), downregulation of microbial metabolic pathways, and reduced plasma tryptophan, suggesting a causal role of gut dysbiosis in SAD ...
Yu‐Chao Feng, Xiao‐Xuan Liu, Huan Yu, Rui Liu, Ting‐Song Pang, Hua‐Ning Wang, Zheng‐Wu Peng   +6 more
wiley   +1 more source

Advances in capsule-based fecal microbiota transplantation: clinical applications and innovations. [PDF]

J Transl Med
Yu H, Zhang Y, Yang D, Luo H, Zhou Y.
europepmc   +1 more source

Identification of Key Microbial Signatures Associated With Breast Cancer: Machine Learning‐Based Approaches Using Gut Microbiome Data

Cancer Medicine, Volume 15, Issue 6, June 2026.
This study investigates the potential of the gut microbiome as a non‐invasive biomarker for breast cancer (BC) using a machine learning (ML) framework. Utilizing 16S rRNA gene sequencing data from the NCBI database for 962 individuals (520 BC patients and 442 healthy controls), we processed the sequences through a FastQC, QIIME2, and DADA2 pipeline ...
Md. Tanvir Ahmed, Samriddha Majumdar, Abdullah Al Noman, Md. Jahangir Alam, Md. Jahangir Alam   +4 more
wiley   +1 more source

Mechanistic insights into fecal microbiota transplantation for the treatment of ulcerative colitis: analysis of the STOP-Colitis trial. [PDF]

J Crohns Colitis
Quraishi MN, Moakes CA, Yalchin M, Blackwell C, Segal J, Ives NJ, Magill L, Manzoor SE, Gerasimidis K, McMullan C, Mathers J, Horniblow R, Loi S, Kaur M, Loman NJ, Sharma N, Hawkey P, McCune V, Quick J, Nicholls S, McMurray C, Nichols B, Svolos V, Raguideau S, Kerbiriou C, Oo YH, Beggs AD, Crees N, Hansen R, Hart AL, Gaya DR, Quince C, Iqbal TH.   +32 more
europepmc   +1 more source

Immunotherapy 3.0: Breakthroughs Steering the Next Generation of Cancer Control

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Hematologic disorders, including sickle cell disease, anemias, hemoglobinopathies, leukemias, lymphomas, and bleeding disorders, constitute a substantial and growing burden of morbidity and mortality across Africa. Structural health system constraints—limited diagnostic capacity, shortages of trained hematology specialists ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source