Results 71 to 80 of about 738,105 (258)

Effects of semaglutide on metabolism and gut microbiota in high-fat diet-induced obese mice

Frontiers in Pharmacology
BackgroundThe purpose of this study was to explore how semaglutide, a GLP-1RA, regulates serum metabolism and gut microbiota to improve obesity in mice and whether fecal microbiota transplantation (FMT) can transmit the beneficial effects of semaglutide ...
Luyan Sun, Bingqing Shang, Suyuan Lv, Guolong Liu, Qiu Wu, Yue Geng   +5 more
doaj   +1 more source

Modern approaches to the correction of the gut microbiota

Медицинский совет, 2021
The article presents modern data on the formation, structure, functions and possibilities of correction of the gut microbiota. The gut microbiota is a collection of living organisms that inhabit the human intestine and form a complex microecological ...
N. V. Sturov, S. V. Popov, V. A. Zhukov
doaj   +1 more source

Targeting the microbiome: from probiotics to fecal microbiota transplantation

, 2018
Editorial summary The modern techniques of microbiome science can be applied to the development and evaluation of all microbiota-directed products, including probiotics and fecal microbiota ...
Alexander Khoruts
core   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Fecal microbiota transplantation in HIV: A pilot placebo-controlled study [PDF]

, 2021
Changes in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio 
Dronda, Fernando, Martínez-Sanz, Javier, Talavera, Alba, Budree, Shrish, Ron, Raquel, Pérez-Molina, José Antonio, Vallejo, Alejandro, Talavera-Rodríguez, Alba, Serrano-Villar, Sergio, Lanza, Val F., Gutiérrez, Carolina, Elliott, Ryan J, Herrera, Sabina, Zamora, Javier, Manzano, Mónica, Moya, Andrés, Vivancos, María Jesús, Lanza, Val F, Osman, Majdi, Pérez-Molina, José A., Ansa, Uxua, Zamora, Javier; id_orcid, Moreno, Santiago, Madrid, Nadia, Navia Lombán, Beatriz, Navia, Beatriz, Elliott, Ryan J., Moya, A, Gosalbes, María José, Javier Zamora, Sabina Herrera, Sergio Serrano-Villar, Carolina Gutiérrez, María José Gosalbes, Nadia Madrid, Santiago Moreno, Javier Martínez-Sanz, María Jesús Vivancos, Uxua Ansa, José A. Pérez-Molina, Ryan J. Elliott, Majdi Osman, Fernando Dronda, Shrish Budree, Raquel Ron, Andrés Moya, Alba Talavera-Rodríguez, Mónica Manzano, Val F. Lanza, Beatriz Navia, Alejandro Vallejo   +50 more
core   +1 more source

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

Advanced Science, EarlyView.
This study employs a spouse‐pair cohort design and an idopNetwork model that integrates evolutionary game theory, predator‐prey dynamics, and developmental modularity theory to reconstruct maximally informative microbial interaction networks. This approach reveals how interspecies interactions drive the phenotypic plasticity of the gut microbiota in ...
Huizhen Li, Jiayi Li, Ang Dong, Xiaoyan Guo, Qiuyue Tu, Zelin Feng, Haojia Lin, Yanru Zhang, Yuxuan Hao, Huiying Gong, Yihan Meng, Yu Wang, Shing‐Tung Yau, Xiaocang Cao, Rongling Wu, Xinjuan Liu   +15 more
wiley   +1 more source

Fecal microbiota transplantation [PDF]

, 2015
Fecal microbiota transplantation (FMT) represents the most promising free-antibiotic therapy in the management of patients with infection by Clostridium difficile, recurrent or refractory to treatment with antibiotics.
Bosques Padilla, Francisco Javier, González Altamirado, J., Garza González, Elvira, Maldonado Garza, Héctor Jesús   +3 more
core   +1 more source

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

Advanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang, Miaoyu Li, Tiantian Li, Xiaojie Zang, Haiyang Shi, Yaru Liu, Chengcheng Zhang, Jianxin Zhao, Qixiao Zhai, Wei Chen, Fengwei Tian   +10 more
wiley   +1 more source

Additional file 1 of Medical students’ perception on fecal microbiota transplantation

, 2019
Additional file 1. Questionnaire regarding fecal microbiota transplantation (FMT)
Adriana Baban (7487132), Dan L. Dumitrascu (8571501), Petru C. Madar (8571498), Oana Petre (7487129)   +3 more
core   +1 more source

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source