Results 91 to 100 of about 65,676 (304)

Advances in Microfluidic Cochlea‐On‐A‐Chip

open access: yesAdvanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen   +10 more
wiley   +1 more source

Malignant Hepatoblast‐Like Cells Sustain Stemness via IGF2‐Dependent Cholesterol Accumulation in Hepatoblastoma

open access: yesAdvanced Science, EarlyView.
Hepatoblastoma, an aggressive childhood liver tumor, origins from malignant hepatoblast‐like cells. Single‐cell analysis reveals IGF2‐driven pathways promoting malignancy. Targeting these pathways offers promising treatments, with serum IGF2 as a potential diagnostic biomarker.
Miao Ding   +12 more
wiley   +1 more source

Developing Quorum Sensing‐Based Collaborative Dynamic Control System in Halomonas TD01

open access: yesAdvanced Science, EarlyView.
A standardized and streamlined inducer‐free quorum sensing (QS)‐based collaborative dynamic control pattern is developed for sufficient gene expression control in Halomonas TD by mixing two engineered cells, cells A and B. Proof‐of‐concept studies are designed to test the dynamic control performance in mixed cultures in fed‐batch conditions.
Yi‐Na Lin   +12 more
wiley   +1 more source

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

open access: yesAdvanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng   +11 more
wiley   +1 more source

Optimal Feeding Trajectories Design for E. coli Fed-batch Fermentations [PDF]

open access: yesInternational Journal Bioautomation, 2010
In this paper optimal control algorithms for two E. coli fed-batch fermentations are developed. Fed-batch fermentation processes of E. coli strain MC4110 and E. coli strain BL21(DE3)pPhyt109 are considered.
Olympia Roeva   +2 more
doaj  

UniMap: Type‐Level Integration Enhances Biological Preservation and Interpretability in Single‐Cell Annotation

open access: yesAdvanced Science, EarlyView.
UniMap introduces a novel multiselective adversarial network that functions as a discerner in single‐cell dataset integration. It enables type‐level integration, ensuring accurate cell type annotation across diverse biological contexts while preserving shared and domain‐specific features.
Haitao Hu   +11 more
wiley   +1 more source

Effects of stocking density on the performance of lettuce (Lactuca sativa) in small‐scale lettuce‐Nile tilapia (Oreochromis niloticus L.) aquaponic system

open access: yesAquaculture, Fish and Fisheries, Volume 2, Issue 6, Page 458-469, December 2022., 2022
Graphical Abstract : Aquaponics, hydroponics, stocking density. Abstract Aquaponics incorporates aquaculture with hydroponics, whose principles and operations largely remain untested. Currently, there is a knowledge gap on the performance of aquaponic systems used for fish production under different stocking densities.
Josiah A. Sabwa   +5 more
wiley   +1 more source

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