Results 121 to 130 of about 65,676 (304)

Tolerance of engineered Rhodosporidium toruloides to sorghum hydrolysates during batch and fed-batch lipid production. [PDF]

open access: yesBiotechnol Biofuels Bioprod, 2023
Woodruff W   +4 more
europepmc   +1 more source

STATE ESTIMATION AND PARAMETER IDENTIFICATION IN A FED-BATCH PENICILLIN PRODUCTION PROCESS

open access: gold, 1999
José Alberto Domingues Rodrigues   +2 more
openalex   +1 more source

A Versatile High‐Throughput Single‐Cell Screening Platform for Profiling Antigen‐Specific Long‐Lived B Cells in Blood and Bone Marrow

open access: yesAdvanced Science, EarlyView.
The MoSMAR‐chip platform provides a high‐throughput and cost‐effective tool for identifying and characterizing antigen‐specific antibody‐secreting cells (ASCs) and memory B cells (MBCs) at the single‐cell level. The ASCs from coronavirus disease 2019 (COVID‐19) vaccine‐immunized mice were successfully analyzed, revealing diverse neutralizing antibodies
Tian Zhao   +13 more
wiley   +1 more source

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

open access: yesAdvanced Science, EarlyView.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian   +16 more
wiley   +1 more source

Sulfate limitation increases specific plasmid DNA yield and productivity in E. coli fed-batch processes. [PDF]

open access: yesMicrob Cell Fact, 2023
Gotsmy M   +6 more
europepmc   +1 more source

PLXDC1+ Tumor‐Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study uncovers the activation, heterogeneity, and regulatory roles of pancreatic stellate cells (PSCs) at single‐cell and spatial levels. It further identifies PLXDC1+ PSCs near aggressive LRRC15+ cancer‐associated myofibroblasts and SPP1+ macrophages, forming a desmoplastic and immunosuppressive tumor niche that promotes CD8+ T cell exhaustion ...
Yanhua Du   +12 more
wiley   +1 more source

Twin neural network regression

open access: yesApplied AI Letters, Volume 3, Issue 4, December 2022., 2022
We propose to reformulate a regression problem into predicting differences between target values. This allows for leveraging consistency conditions which can be used as uncertainty estimates and enable the production of an ensemble of predictions while training only a single neural network.
Sebastian Johann Wetzel   +3 more
wiley   +1 more source

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li   +8 more
wiley   +1 more source

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