Results 301 to 310 of about 103,350 (330)
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Metabolically optimised BHK cell fed-batch cultures
Journal of Biotechnology, 2000The aim of this work was the optimisation of a fed-batch culture by metabolic confinement of BHK21 cells producing an antibody/cytokine fusion protein with potential application in tumour-targeted therapy. Previous results showed that at very low nutrient concentrations, a metabolic shift towards more efficient metabolic pathways occurs.
H J, Cruz, J L, Moreira, M J, Carrondo
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Reachability of nonlinear fed‐batch fermentation processes
International Journal of Robust and Nonlinear Control, 2002AbstractThe reachability of a simple nonlinear fed‐batch fermentation process model is investigated in this paper. It is shown that the known difficulties of controlling such processes are primarily caused by the fact that the rank of the reachability distribution is always less than the number of state variables.Furthermore, a co‐ordinates ...
Szederkényi, G. +2 more
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2013
Fed-batch reactor is based on feeding of a growth limiting nutrient substrate to a culture. Cell growth and fermentation can be controlled by the feeding strategy. The fed-batch strategy is typically used to reach a high cell density in the bioreactor or mimic a continuous culture. Mostly the feed solution is highly concentrated.
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Fed-batch reactor is based on feeding of a growth limiting nutrient substrate to a culture. Cell growth and fermentation can be controlled by the feeding strategy. The fed-batch strategy is typically used to reach a high cell density in the bioreactor or mimic a continuous culture. Mostly the feed solution is highly concentrated.
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2020
The cells used in cell culture processes are all derived from animals. Their genetic and epigenetic control circuits and their physiology have evolved to carry out the physiological functions of the tissue from which they were derived, not to sustain themselves and proliferate in in vitro culture.
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The cells used in cell culture processes are all derived from animals. Their genetic and epigenetic control circuits and their physiology have evolved to carry out the physiological functions of the tissue from which they were derived, not to sustain themselves and proliferate in in vitro culture.
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Adaptive Optimal Control of Fed-Batch Alcoholic Fermentation
Applied Biochemistry and Biotechnology, 1998An adaptive control scheme is developed for the optimization of a fed-batch ethanol production process. The fermentation process is modeled by an hybrid neural model combining mass balance equations and neural networks, used to represent the kinetic rates.
T L, Alves +3 more
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Fed-batch operation of stirred reactors
Chemical Engineering Science, 1987Abstract Numerical algorithm for the computation of the dependence of periodic solutions on parameters in fed-batch or periodically operating reactors is described. Results for the simulation of a simple model of anaerobic digester and of a first order exothermic reaction are then discussed and various types of m -periodic solutions are presented ...
Z. Kubičkova, M. Kubiček, M. Marek
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Extended cyclic fed-batch tylosin fermentations
Biotechnology Letters, 1987Biosynthesis of the macrolide antibiotic tylosin was studied in fed-batch fermentations. When glucose and sodium glutamate were fed to the fermentation in a cyclic square wave fashion with a period of 24 hours, it was possible to maintain high initial rates of tylosin biosynthesis for up to 240 hours before the synthetic rate decreased. By adding basic
P. P. Gray, K. Vu-Trong
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Fed-batch versus batch fermentation
Bioprocess Engineering, 1994This article concerns the comparison between batch and fed-batch fermentation based on productivity and including the analysis of the implications on product manufacturing cost.
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Robust operation of fed batch fermenters
Bioprocess Engineering, 1998Optimisation of fed batch fermenters can substantially increase the profitability of these processes. Optimal control of a fed batch fermenter is usually based on a nominal process model. Parameter uncertainties are not taken into account. Simulation studies show that results obtained with fixed nominal model parameters can be quite sensitive to the ...
C. Kuhlmann +2 more
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Fed-batch fermentation for ergosterol production
Process Biochemistry, 2003Abstract The relationship between the fermentation parameters pH, DO and the concentrations of glucose, biomass and the ergosterol content of Saccharomyces cerevisiae in different fed-batch methods are discussed. Different fed-batch methods including constant feed rate fed-batch, constant glucose concentration fed-batch, exponential fed-batch, DO ...
Hua Gao, Tianwei Tan
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