Results 91 to 100 of about 19,074 (293)

On‐deck pH measurement with integrated feedback control on a micro‐scale platform for monoclonal antibody low pH viral inactivation

open access: yesBiotechnology Progress, EarlyView.
Integrating an automated, on‐deck pH measurement method with feedback control enables precise, real‐time pH adjustment during low pH viral inactivation on a micro‐scale platform. Abstract The increasing demand for efficient monoclonal antibody manufacturing has accelerated the adoption of high throughput process development (HTPD) platforms, which ...
Paras Sharma   +5 more
wiley   +1 more source

CONSTANT-VOLUME FED-BATCH OPERATION FOR HIGH DENSITY CULTIVATION OF HYPERTHERMOPHILIC AEROBES

open access: yes, 2019
When hyperthermophilic archaebacteria are cultivated under aerobic conditions, the loss of the culture volume becomes significant due to vaporization of water with aeration. To eliminate the problems caused by evaporation of the medium, we have devised a
Park, CB, Lee, SB
core   +1 more source

β‐1,4‐galactosyltransferase 1 inhibitors modulate cellular N‐glycan profiles

open access: yesBiotechnology Progress, EarlyView.
Graphical representation of the study workflow used to investigate the effects of known in vitro galactosyltransferase inhibitors on cell culture performance and recombinant IgG galactosylation. Abstract N‐glycosylation is a key post‐translational modification of proteins influencing their physicochemical properties as well as biological activity. This
Jaka Kranjc   +4 more
wiley   +1 more source

Fed-batch process for the psychrotolerant marine bacterium Pseudoalteromonas haloplanktis

open access: yesMicrobial Cell Factories, 2010
Background Pseudoalteromonas haloplanktis is a cold-adapted γ-proteobacterium isolated from Antarctic sea ice. It is characterized by remarkably high growth rates at low temperatures. P. haloplanktis is one of the model organisms of cold-adapted bacteria
Lalk Michael   +5 more
doaj   +1 more source

Adaptive control of the E. coli-specific growth rate in fed-batch cultivation based on oxygen uptake rate. [PDF]

open access: yesComput Struct Biotechnol J, 2023
Urniezius R   +5 more
europepmc   +1 more source

Mathematical Description of Functional States in E. coli Fed-batch Cultivation Processes [PDF]

open access: yesBioautomation, 2007
This paper presents an overview of a biochemical correspondence to defined functional states based on specific metabolic mechanisms. For Escherichia coli fed-batch cultivation processes a set of four functional states is considered.
Kalin Kosev   +2 more
doaj  

Glucose limited feed strategy leads to increased production of fusicocca-2,10(14)-diene by Saccharomyces cerevisiae

open access: yesAMB Express, 2018
Fusicocca-2,10(14)-diene (FCdiene) is a diterpene which is interesting as a precursor of the anti-cancer drug fusicoccin A and therefore for pharmaceutical applications. Production of FCdiene using a genetically modified Saccharomyces cerevisiae has been
Lisa Marie Halka   +4 more
doaj   +1 more source

De novo Biosynthesis of Biodiesel by Escherichia coli in Optimized Fed-Batch Cultivation

open access: yesPLoS ONE, 2011
Biodiesel is a renewable alternative to petroleum diesel fuel that can contribute to carbon dioxide emission reduction and energy supply. Biodiesel is composed of fatty acid alkyl esters, including fatty acid methyl esters (FAMEs) and fatty acid ethyl esters (FAEEs), and is currently produced through the transesterification reaction of methanol (or ...
Yangkai Duan   +4 more
openaire   +4 more sources

Determining the Nutritional Potential of Ancient Wheat Species: A Closer Look at Starch and Protein Digestibility, and Phenolic Acid Content

open access: yesCereal Chemistry, EarlyView.
ABSTRACT Background and Objectives The recent trend towards healthy food choices and sustainable agriculture has revived interest in underutilized wheat species such as emmer, einkorn, and spelt. Given these developments, the objective of the study was to compare the differences in chemical composition and digestibility characteristics among ...
Sathsara Deyalage   +5 more
wiley   +1 more source

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