Results 41 to 50 of about 28,581 (261)
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses
Advanced Healthcare Materials, EarlyView.This study presents a novel 3D Neuron‐on‐Chip model that can maintain human PSC‐derived excitatory prefrontal cortex neurons in 3D hydrogels and can be used to monitor neuronal injury responses over time. Results show injury‐induced acute neuronal excitotoxicity, declining neuronal connectivity, and the activation of a neurodegenerative, SASP‐like ...
Ruiping Tang +16 more
wiley +1 more source
Investigation the effect of olive oil feeding strategies on Yarrowia lipolytica lipase production
Biological Journal of Microorganism, 2015 Introduction: Lipase of the yeast Yarrowia lipolytica used in detergents, cosmetics, pharmaceuticals and food industries. This enzyme production depends on medium composition, especially carbon source. The purpose of this study was to investigate ...
Farshad Darvishi, Barumand Hosseini
doaj
Advanced Healthcare Materials, EarlyView.Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source
Navigating Lipid Nanostructure Design Space Through Continuous Microfluidic Automation
Advanced Materials, EarlyView.LipidXplorer is a novel microfluidic platform which enables rapid navigation of lipid particle design space for high‐resolution phase mapping, lipid nanoparticle optimization, membrane biophysics, and functional nanomaterial discovery. It combines programmable composition control, continuous nanoparticle formation, and automated well‐plate collection ...
Bradley Diggines +10 more
wiley +1 more source
Acetamide degradation by a continuous-fed batch culture ofBacillus sphaericus
Applied Biochemistry and Biotechnology, 1998 The methanogenesis of acetamide occurs through a two-step reaction in methanogenic sludges. First, acetamide is hydrolyzed to acetate and ammonia by a strict aerobic bacterium (Bacillus sphaericus), then acetate is used by Bacillus as carbon source or converted to methane by methanogens.
Ramirez, F. +4 more
openaire +3 more sources
Advanced Materials, EarlyView.Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi +3 more
wiley +1 more source
AMB Express, 2019 The cap protein is encoded by the orf2 gene of porcine circovirus type 2 (PCV2) has the main antigen epitope of PCV2 and can form virus-like particles (VLPs), which are expressed in insect cells.
Wenlong Cao +3 more
doaj +1 more source
De Novo Autogenic Engineered Living Functional Materials
Advanced Materials, EarlyView.A versatile platform for de novo autogenic engineered living materials is presented, leveraging protein mining, computational modeling, and synthetic biology. By reprogramming the Escherichia coli curli machinery with β‐solenoid proteins from non‐model bacteria, macroscopic biomaterials with enhanced mechanical properties, UV‐C irradiation protection ...
Hoda M. Hammad +9 more
wiley +1 more source
Optimization of cyclosporin A production by Beauveria nivea in continuous fed-batch fermentation [PDF]
Archives of Biological Sciences, 2011 To develop the effective control method for fed-batch culture of cyclosporin A production, we chose fructose, L-valine and (NH4)2HPO4 as feeding nutrients and compared their productivities in relation to different concentrations.
Dong Huijun +3 more
doaj +1 more source