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Industrial Fed-Batch Fermentation Monitoring
IFAC Proceedings Volumes, 1997Abstract A multivariate statistical model is developed and used for fault diagnosis of an industrial fed-batch fermentation process. Process faults may be detected on-line using existing measurements. In the applied approach the modelling is entirely data driven. Several data sets (25) are used to develop a model for cultivation behaviour. This model
Lars Gregersen +2 more
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Supervision of fed-batch fermentations
Chemical Engineering Journal, 1999Process faults may be detected on-line using existing measurements based upon modelling that is entirely data driven. A multivariate statistical model is developed and used for fault diagnosis of an industrial fed-batch fermentation process. Data from several (25) batches are used to develop a model for cultivation behaviour.
Lars Gregersen, Sten Bay Jørgensen
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2013
Fed-batch reactor is based on feeding of a growth limiting nutrient substrate to a culture. Cell growth and fermentation can be controlled by the feeding strategy. The fed-batch strategy is typically used to reach a high cell density in the bioreactor or mimic a continuous culture. Mostly the feed solution is highly concentrated.
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Fed-batch reactor is based on feeding of a growth limiting nutrient substrate to a culture. Cell growth and fermentation can be controlled by the feeding strategy. The fed-batch strategy is typically used to reach a high cell density in the bioreactor or mimic a continuous culture. Mostly the feed solution is highly concentrated.
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Metabolically optimised BHK cell fed-batch cultures
Journal of Biotechnology, 2000The aim of this work was the optimisation of a fed-batch culture by metabolic confinement of BHK21 cells producing an antibody/cytokine fusion protein with potential application in tumour-targeted therapy. Previous results showed that at very low nutrient concentrations, a metabolic shift towards more efficient metabolic pathways occurs.
H J, Cruz, J L, Moreira, M J, Carrondo
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2020
The cells used in cell culture processes are all derived from animals. Their genetic and epigenetic control circuits and their physiology have evolved to carry out the physiological functions of the tissue from which they were derived, not to sustain themselves and proliferate in in vitro culture.
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The cells used in cell culture processes are all derived from animals. Their genetic and epigenetic control circuits and their physiology have evolved to carry out the physiological functions of the tissue from which they were derived, not to sustain themselves and proliferate in in vitro culture.
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Reachability of nonlinear fed‐batch fermentation processes
International Journal of Robust and Nonlinear Control, 2002AbstractThe reachability of a simple nonlinear fed‐batch fermentation process model is investigated in this paper. It is shown that the known difficulties of controlling such processes are primarily caused by the fact that the rank of the reachability distribution is always less than the number of state variables.Furthermore, a co‐ordinates ...
Szederkényi, G. +2 more
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Model structures for batch and fed-batch ethanol fermentations
2019 IEEE CHILEAN Conference on Electrical, Electronics Engineering, Information and Communication Technologies (CHILECON), 2019Parameter estimation is one of the most challenging steps while modelling a biological process, due to the inherent complexity of this type of processes and the difficulty in obtaining reliable experimental data. A common modelling practice in this area is to use a batch culture to estimate model parameters and then use these values to simulate and ...
K. Serebrinsky +3 more
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Batch and Fed‐Batch Degradation of Enrofloxacin by the Fenton Process
Chemical Engineering & Technology, 2017AbstractEnrofloxacin is a synthetic second‐generation fluoroquinolone used as an antimicrobial agent exclusively in veterinary medicine. To simulate the treatment of wastewater contaminated by enrofloxacin, four‐day long fed‐batch runs were carried out according to the Fenton process with an enrofloxacin solution as model, to which hydrogen peroxide ...
Frade, Verônica M. F. +4 more
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Fermentation kinetics of recombinant yeast in batch and fed‐batch cultures
Biotechnology and Bioengineering, 1992AbstractFed‐batch cultures of recombinant microorganisms have attracted attention as they can separate cell growth stage from cloned‐gene expression phase during fermentations. In this work, the effect of different glucose feeding strategies on cell growth and cloned gene expression was studied during aerobic fed‐batch fermentations of recombinant ...
A, Patkar, J H, Seo
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Growth of Photorhabdus luminescens in batch and glucose fed-batch culture
Applied Microbiology and Biotechnology, 2000Photorhabdus luminescens, a bacterial symbiont of entomopathogenic biocontrol nematodes, was grown in batch and glucose fed-batch culture. The cell density, bioluminescence, production of antibiotic substances, number of cells with inclusion bodies, glucose concentration and oxygen uptake rate were recorded.
T, Jeffke +4 more
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