Results 41 to 50 of about 165,251 (363)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Evaluating additives for swine rations (1993) [PDF]

, 1993
Swine producers today are making decisions about feed additives, which are promoted as an aid in reducing feed required per pound of gain. Additives on the market have been selected from a large number investigated for use in treatment of swine diseases ...
Rea, John Cyrus, Veum, Trygve Lauritz, 1940-   +1 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The comparative evaluation of complex drugs based on fipronil for ectoparasitosis of dogs and cats

Ukrainian Journal of Veterinary and Agricultural Sciences, 2021
The article presents data on the effectiveness of new domestic antiparasitic drug “Insectostop for dogs and cats” in comparison to the reference drugs “Burdi Fipro for dogs” and “Burdi Fipro for cats” that is used for therapeutic and prophylactic ...
O. L. Tishyn, I. D. Yuskiv, L. L. Yuskiv, Zn. M. Perih, O. M. Bogach   +4 more
doaj   +1 more source

Synergistic Effects of Probiotics and Phytobiotics on the Intestinal Microbiota in Young Broiler Chicken [PDF]

, 2019
Probiotics and phytobiotics have been studied as in-feed antibiotic alternatives for decades, yet there are no studies on their possible symbiotic effects.
Boroojeni, Farshad Goodarzi, Dadi, Temesgen, Ren, Hao, Saliu, Eva-Maria, Vahjen, Wilfried, Zentek, Jürgen   +5 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Evaluation of the method for quantitative determination of soybean line MON 89788 by PCR-RF method

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки
The method for quantitative determination of soybean line MON 89788 by polymerase chain reaction was evaluated in accordance with European standards and norms.
G. V. Kushnir, V. I. Kushnir, G. P. Ryvak, B. V. Gutyj, T. V. Marchyshak, G. Yu. Fedor, L. V. Kurilas   +6 more
doaj   +1 more source

Influence of enterococci on the sensitivity of opportunistic microflora to antibiotics

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Гжицького. Серія: Сільськогосподарські науки, 2021
The article presents the results of determining the ability of enterococci isolated from traditional Carpathian cheese to affect the antibiotic sensitivity of opportunistic gram-positive and gram-negative microorganisms, particularly test strains of S ...
I. I. Kushnir, I. S. Semen, O. Y. Tsisaryk, I. M. Kushnir   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Influence of single oral administration of taurine-dextrin associate on concentration of amino acids in rat plasma

Біологія тварин, 2020
The aim of the study was to test the ability of dextrin particles of different sizes, modified with N-stearylglutamic acid, to increase the transport of taurine into the blood plasma of rats.
R. D. Ostapiv, O. I. Lukashchuk, V. Ya. Samaryk, M. I. Nagornyak, S. M. Varvarenko   +4 more
doaj   +1 more source