Results 71 to 80 of about 150,745 (309)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

When Less Is More – Discrete Tactile Feedback Dominates Continuous Audio Biofeedback in the Integrated Percept While Controlling a Myoelectric Prosthetic Hand

open access: yesFrontiers in Neuroscience, 2019
State of the art myoelectric hand prostheses can restore some feedforward motor function to their users, but they cannot yet restore sensory feedback. It has been shown, using psychophysical tests, that multi-modal sensory feedback is readily used in the
Leonard F. Engels   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Effects of Visual Feedback During Recumbent Stepping in Individuals With Chronic Stroke

open access: yesArchives of Rehabilitation Research and Clinical Translation, 2020
Objective: To investigate the effects of intermittent visual feedback (using the Balanced Power program on the NuStep Transitt) during recumbent stepping on strength, balance, and functional mobility in individuals with chronic stroke.
Vicky Pardo, PT, DHS   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

VibroTac: An Ergonomic And Versatile Usable Vibrotactile Feedback Device

open access: yes, 2010
— This paper presents an ergonomic vibrotactile feedback device for the human arm. Due to the developed con- cept, the device can be used for a large spectrum of applications and a wide range of arm diameters since vibration segments are self ...
Ende, Tobias   +3 more
core  

Altered Sensory Feedbacks in Pianist's Dystonia: the altered auditory feedback paradigm and the glove effect

open access: yesFrontiers in Human Neuroscience, 2013
Background: This study investigates the effect of altered auditory feedback (AAF) in musician's dystonia (MD) and discusses whether altered auditory feedback can be considered as a sensory trick in MD.
Felicia Pei-Hsin Cheng   +2 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Sensory Feedback Can Coordinate the Swimming Activity of the Leech

open access: yes, 1999
Previous studies showed that sensory feedback from the body wall is important and sometimes critical for generating normal, robust swimming activity in leeches.
W. Otto Friesen, Xintian Yu, Binh Nguyen
core   +1 more source

Haptic Feedback Systems for Lower-Limb Prosthetic Applications: A Review of System Design, User Experience, and Clinical Insights

open access: yesBioengineering
Systems presenting haptic information have emerged as an important technological advance in assisting individuals with sensory impairments or amputations, where the aim is to enhance sensory perception or provide sensory substitution through tactile ...
Mohammadmahdi Karimi   +8 more
doaj   +1 more source

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