Results 141 to 150 of about 1,918,001 (296)
TechnologiesIt is demonstrated that neuromorphic materials designed for computational tasks can be effectively implemented by drawing an analogy with trigger-based systems built upon classical binary elements.
Dina Shaltykova +4 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Competency Assessment in Training in African Countries
Journal of Abdominal Wall SurgeryIntroductionProgress through surgical training in many institutions in Africa is based on duration of apprenticeship, logbook activity, and success in prescribed examinations. Objective assessment of competency is less rigorous.
Jacob A. Akoh
doaj +1 more source
Feedback on feedback on feedback: It's feedforward. (Response to commentators) [PDF]
, 2000 Contains fulltext : 16958.pdf (Publisher’s version ) (Open Access)
Norris, D., McQueen, J., Cutler, A.
openaire +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Pedagogical Feedback for Computer-based Sport Training [PDF]
Feedback in Computer-based Sport Training (CBST) may be synthetically designed to allow athletes to practise in a more effective way and enhance their skill acquisition.
Gilbert, Lester +2 more
core
Young people's understanding of mental health and mental illness: a focus group study for Greater Glasgow NHS Board [PDF]
, 2002 This qualitative research study explores the opinions of a sample of young people in Glasgow and their concept of mental health. The aim was to look at the programme designed by the Glasgow Stigma Strategy before it was rolled out into all secondary ...
core +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source