Results 81 to 90 of about 282,811 (270)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Output-Feedback and Inverse Optimal Control of a Class of Stochastic Nonlinear Systems with More General Growth Conditions

Journal of Applied Mathematics, 2013
This paper investigates the problem of output-feedback stabilization for a class of stochastic nonlinear systems in which the nonlinear terms depend on unmeasurable states besides measurable output.
Liu Jianwei, Guo Longchuan, Zuo Xin, Liang Huaqing   +3 more
doaj   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

Advanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian, Frédéric Demoly, Mohammad Lakhi, Bernard Rolfe, Mahdi Bodaghi   +4 more
wiley   +1 more source

Hybrid Feedback Stabilization of Fuzzy Nonlinear Systems

Journal of Control Science and Engineering, 2011
This paper is concerned with the problem of stabilizing one family of fuzzy nonlinear systems by means of fuzzy quantized feedback. The hybrid control strategy originating in earlier work by Brockett and Liberzon(2000) and Liberzon (2003) relies on the ...
Yingqi Zhang, Caixia Liu, Xiaowu Mu
doaj   +1 more source

Parametrical Non-Complex Tests to Evaluate Partial Decentralized Linear-Output Feedback Control Stabilization Conditions from Their Centralized Stabilization Counterparts

Applied Sciences, 2019
This paper formulates sufficiency-type linear-output feedback decentralized closed-loop stabilization conditions if the continuous-time linear dynamic system can be stabilized under linear output-feedback centralized stabilization. The provided tests are
Manuel De la Sen, Asier Ibeas
doaj   +1 more source

Neural Correlates of Multisensory Integration for Feedback Stabilization of the Wrist. [PDF]

Front Integr Neurosci, 2022
Suminski AJ, Doudlah RC, Scheidt RA.
europepmc   +1 more source

Quantum Emitters in Hexagonal Boron Nitride: Principles, Engineering and Applications

Advanced Functional Materials, EarlyView.
Quantum emitters in hexagonal boron nitride have emerged as a promising candidate for quantum information science. This review examines the fundamentals of these quantum emitters, including their level structures, defect engineering, and their possible chemical structures.
Thi Ngoc Anh Mai, Md Shakhawath Hossain, Nhat Minh Nguyen, Yongliang Chen, Chaohao Chen, Xiaoxue Xu, Quang Thang Trinh, Toan Dinh, Toan Trong Tran   +8 more
wiley   +1 more source

Stabilization in distribution of hybrid stochastic differential delay equations with Lévy noise by discrete-time state feedback controls

AIMS Mathematics
This paper was concerned with stabilization in distribution by feedback controls based on discrete-time state observations for a class of nonlinear stochastic differential delay equations with Markovian switching and Lévy noise (SDDEs-MS-LN).
Jingjing Yang, Jianqiu Lu
doaj   +1 more source