Results 31 to 40 of about 1,126,222 (249)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Bifidobacterium-dominated fecal microbiome in dairy calves shapes the characteristic growth phenotype of host

npj Biofilms and Microbiomes
The dominant bacteria in the hindgut of calves play an important role in their growth and health, which could even lead to lifelong consequences. However, the identification of core probiotics in the hindgut and its mechanism regulating host growth ...
Yimin Zhuang, Shuai Liu, Duo Gao, Yiming Xu, Wen Jiang, Tianyu Chen, Jianxin Xiao, Jingjun Wang, Guobin Hou, Sumin Li, Xinjie Zhao, Yanting Huang, Shangru Li, Siyuan Zhang, Mengmeng Li, Wei Wang, Shengli Li, Zhijun Cao   +17 more
doaj   +1 more source

Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes

Animals
Variation in coat color among equids has attracted significant interest in genetics and breeding research. The range of colors is primarily determined by the type, concentration, and distribution of melanin pigments, with the balance between eumelanin ...
Xiaotong Liu, Yongdong Peng, Xinhao Zhang, Xinrui Wang, Wenting Chen, Xiyan Kou, Huili Liang, Wei Ren, Muhammad Zahoor Khan, Changfa Wang   +9 more
doaj   +1 more source

Priming of intestinal cytoprotective genes and antioxidant capacity by dietary phytogenic inclusion in broilers

Animal Nutrition, 2020
The potential of a phytogenic premix (PP) based on ginger, lemon balm, oregano and thyme to stimulate the expression of cytoprotective genes at the broiler gut level was evaluated in this study.
Konstantinos C. Mountzouris, Vasileios V. Paraskeuas, Konstantinos Fegeros   +2 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Shredlage Processing Affects the Digestibility of Maize Silage

Agronomy, 2022
Maize silage is one of the most important feeds for ruminant nutrition and various production methods can have a significant impact on their quality, especially the utilization of nutrients.
Filip Jančík, Petra Kubelková, Radko Loučka, Václav Jambor, Dana Kumprechtová, Petr Homolka, Veronika Koukolová, Yvona Tyrolová, Alena Výborná   +8 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Conversion of Brewers’ Spent Grain into Proteinaceous Animal Feed using Solid State Fermentation [PDF]

, 2021
Christos Iliopoulos, Dimitrios Arapoglou, Nikos Chorianopoulos, Γιώργος Μάρκου, Serkos A. Haroutounian   +4 more
openalex   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source