Results 41 to 50 of about 1,126,222 (249)

Diurnal activity budget and feeding activity of grivet monkeys (Chlorocebus aethiops) in Zegie Peninsula, Northern Ethiopia [PDF]

, 2022
Yibelu Yitayih, Esubalew Asmare, Misganaw Mola   +2 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A Randomized Controlled Clinical Trial of Olive Oil Added to Human Breast Milk for Weight Gaining in Very Low Birth Weight Infants

Journal of Family and Reproductive Health, 2011
Objective: Evaluating the effect of vegetable oil, as a supplement to breast milk in increase the weight gaining of VLBW neonates. Materials and methods: In this single blind; Randomized clinical trials , in NICU of Vali-asr Hospital, Tehran University ...
Elaheh Amini, Mamak Shariat, Fatemeh Nayeri, Firoozeh Nili, Bita Ebrahim, Hosein Dalili   +5 more
doaj  

Evaluation of different mathematical models on fitting the in vitro gas production parameters in beef cattle

Scientific Reports
In vitro rumen gas production experiment was conducted with 57 kinds of feedstuff, which were categorized into energy feed, protein feed, and roughage, collected within China.
Jinze Wang, Zhiyu Zhou, Yang Cheng, Hao Wu, Xin Yi, Ziqi Deng, Boping Ye, Saige Liu, Lingyu Ren, Ning Li, Xiaowen Zhu, Wei Li, Simeng Yi, Qingxiang Meng, Zhenming Zhou   +14 more
doaj   +1 more source

Advancements in Genetic Marker Exploration for Livestock Vertebral Traits with a Focus on China

Animals
In livestock breeding, the number of vertebrae has gained significant attention due to its impact on carcass quality and quantity. Variations in vertebral traits have been observed across different animal species and breeds, with a strong correlation to ...
Muhammad Zahoor Khan, Wenting Chen, Bingjian Huang, Xiaotong Liu, Xinrui Wang, Yihong Liu, Wenqiong Chai, Changfa Wang   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Glucose release kinetics of different feed ingredients and their impact on short-term growth of pigs by influencing carbon-nitrogen supply synchronization

Journal of Animal Science and Biotechnology
Background Pigs fed diets with different ingredients but identical nutritional levels show significant differences in growth performance, indicating that growth may also be influenced by the synchronicity of dietary carbon and nitrogen supply. Therefore,
Mingyi Huang, Lei Xue, Yifan Wu, Qinzheng Sun, Yanwei Xu, Jia Li, Xiaoyi Yu, Yu Cao, Jingyi Huang, Zeyu Zhang, Jinbiao Zhao, Dandan Han, Defa Li, Junjun Wang   +13 more
doaj   +1 more source