Results 41 to 50 of about 275,054 (314)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Prácticas proambientales para la sostenibilidad: Impulsando un futuro más verde a través de iniciativas globales y locales

Journal of Behavior and Feeding
En un mundo impactado por el cambio climático y la degradación ambiental, la adopción de prácticas proambientales surge como una de las soluciones clave para alcanzar la sostenibilidad.
Fátima Antonia Montes Garcia, Jose Roberto Espinoza Villegas   +1 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Efectos del consumo de proteína a base de pasto verde de trigo y meditación sobre la oxigenación en sangre en jóvenes del Centro Universitario de los Valles

Journal of Behavior and Feeding
El presente proyecto es un trabajo interdisciplinario que vincula conocimientos de la nutrición y la psicología. Específicamente, se evaluó el efecto del consumo de un suplemento alimenticio a base de pasto verde de trigo (marca Bien Verde) sobre la ...
Laura Vanesa Solano Santos, Luis Alfaro Hernández   +1 more
doaj   +1 more source

<strong>Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons</strong> [PDF]

, 2023
Kwang Kon Kim, Tae Hwan Lee, Byong Seo Park, Dasol Kang, Dong Hee Kim, Bora Jeong, Jin Woo Kim, Hye Rim Yang, Han Rae Kim, Sungho Jin, Sung Hoon Back, Jeong Woo Park, Jae Geun Kim, Byung Ju Lee   +13 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

La inflamación como modulador de la conducta y el comportamiento alimentario durante la enfermedad

Journal of Behavior and Feeding
La respuesta inflamatoria es un fenómeno inmunológico fundamental que se genera tras la infección o señales de daño en el organismo. En este proceso, participan activamente múltiples citocinas, moléculas que, por su pleiotropismo, no solo coordinan ...
Heysel Murillo Cazares, Zyanya Reyes Castillo, Elia Herminia Valdés Miramontes   +2 more
doaj   +1 more source

Feeding regimen modulates zebrafish behavior

PeerJ, 2018
Here we show that the feeding regimen modulates zebrafish (Danio rerio) behavior. With regard to the time elapsed between feeding and behavioral evaluation, fish fed 3 h before behavioral evaluation in the novel tank test (NTT) showed decreased activity and a trend toward an anxiolytic reaction (increased use of the upper section of the aquarium) in ...
Dametto, Fernanda S., Fior, Debora, Idalencio, Renan, Rosa, Joao Gabriel S., Fagundes, Michele, Marqueze, Alessandra, Barreto, Rodrigo E., Piato, Angelo, Barcellos, Leonardo J. G.   +8 more
openaire   +4 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Perinatal programming effects on feeding behavior

Journal of Behavior and Feeding
To address the growing prevalence of obesity and its associated metabolic consequences, it is essential to understand the evolutionary origins of health and disease.
Ana Patricia Zepeda Salvador, Ana Cristina Espinoza Gallardo, Dalila Betsabee Meza Rodríguez, Yadira Vianet Martínez Vázquez, Aida Gabriela Anaya Flores, Sofía Castro Botero, Fernando Chávez Corona, Jorge Adalberto Ramos López, Berenice Sánchez Caballero, Alma Gabriela Martínez Moreno   +9 more
doaj   +1 more source