Results 111 to 120 of about 778,919 (303)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
The Feelings and Their Education
, 1913 THE FEELINGS AND THEIR EDUCATION The Feelings and Their Education (70) (-
Hall, Granville Stanley
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The Feel of Life: Resonance, Race, and Representation
International Journal of Communication, 2015 This article uses examples of the viral circulation of the images of Black people in the new media ecology of television news and YouTube to suggest that the feelings these images evoke exceed the legibility of their semiotic meaning and the promise of ...
Herman Gray
doaj
Emotional intelligence: on the problem of defining the concept
Вестник университетаThe article is devoted to substantiate the need to clarify the definition of emotional intelligence (hereinafter referred to as EI). With consideration to the accumulated data on the neurophysiological foundations of EI and psychological trauma, as well ...
E. N. Rastorgueva
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
SpekiThis special issue, Feeling Forward: Contemporary Nordic perspectives on emotion, affect and feeling in philosophy of education, brings together contributions that examine the role of emotion, feeling and affect in educational theory and practice from ...
Claudia Schumann , Marie Hållander
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
ArtsDrawing on methods and theories from the history of emotions, this paper examines the Twin Stelae that flank the entrance into Ramses II’s Great Temple at Abu Simbel in order to investigate the feelings associated with ancient Egyptian kingship from an ...
Tara Prakash
doaj +1 more source