Results 71 to 80 of about 553,144 (146)

Exploring Nirmatrelvir Derivatives Through P2 Substituent Modifications and Warhead Innovations Targeting the Main Protease of SARS‐CoV‐2

Archiv der Pharmazie, Volume 358, Issue 11, November 2025.
This study explores structural tuning of SARS‐CoV‐2 Mpro inhibitors through P2 position substitutions and novel warheads. Combining computational modeling and biochemical assays, we found that hydrophobic π‐rich groups and uncommon warheads like fluoro‐vinylsulfone or nitrile enhance potency.
Felipe Cardoso Prado Martins, Johannes Lang, Fernanda dos Reis Rocho, Xianxian Wang, Vinícius Bonatto, Jerônimo Lameira, Christian Klein, Carlos Alberto Montanari   +7 more
wiley   +1 more source

Treatment With Remdesivir Alone or in Combination With GS‐441524 in Cats With Ocular Involvement of Feline Infectious Peritonitis: An Observational Case Series

Journal of Veterinary Internal Medicine, Volume 39, Issue 6, November/December 2025.
ABSTRACT Background Remdesivir and GS‐441524 have successfully treated cats with feline infectious peritonitis (FIP) but the changes in associated signs of ocular disease are not reported. Objective Evaluate the response of FIP‐associated signs of ocular disease before and after treatment with remdesivir, GS‐441524, or both.
Amy L. M. M. Andrews, Eneko Izaguirre, Jodie Green, Emma Scurrell, Savina Gogova, Sarah Tayler, Christiane Kafarnik   +6 more
wiley   +1 more source

From Challenge to Cure: A Look at Feline Infectious Peritonitis and Emerging Treatment Strategies and Breakthroughs

Veterinary Sciences
Background: Feline infectious peritonitis (FIP) is a complex and devastating viral disease in cats caused by feline coronavirus (FCoV). While FCoV is commonly encountered and typically innocuous, the emergence of a mutated variant can lead to the ...
Sheema Mir, Mykah Peters, Gloria Penny, Alexis Agsaoa, Mohammad Mir   +4 more
doaj   +1 more source

Diagnostic Methods for Feline Coronavirus: A Review

Veterinary Medicine International, 2010
Feline coronaviruses (FCoVs) are found throughout the world. Infection with FCoV can result in a diverse range of signs from clinically inapparent infections to a highly fatal disease called feline infectious peritonitis (FIP).
Saeed Sharif, Siti Suri Arshad, Mohd Hair-Bejo, Abdul Rahman Omar, Nazariah Allaudin Zeenathul, Amer Alazawy   +5 more
doaj   +1 more source

In vitro hepatic metabolism of mefloquine using microsomes from cats, dogs and the common brush-tailed possum (Trichosurus vulpecula).

PLoS ONE, 2020
Feline infectious peritonitis (FIP) is a systemic, fatal, viral-induced, immune-mediated disease of cats caused by feline infectious peritonitis virus (FIPV). Mefloquine, a human anti-malarial agent, has been shown to inhibit FIPV in vitro.
Aaron Michael Izes, Benjamin Kimble, Jacqueline Marie Norris, Merran Govendir   +3 more
doaj   +1 more source

Priapism in a castrated cat associated with feline infectious peritonitis

, 2008
This report describes a case of feline infectious peritonitis (FIP) in a castrated cat which first presented with the unusual sign of priapism. Laboratory examinations showed increased serum protein content and decreased albumin/globulin ratio.
A. Rota, S. Paltrinieri, S. Jussich, S. Appino, G. Ubertalli   +4 more
core   +2 more sources

Practical Application of Disease Risk Assessment in Native Species Reintroductions: A Case Study of a European Wildcat (Felis silvestris) Population Reinforcement in the Cairngorms National Park

Mammal Review, Volume 55, Issue 4, October 2025.
Disease risk assessment was conducted for the Saving Wildcats reintroduction project of captive‐bred European Wildcats (Felis silvestris) to the Cairngorms National Park. Hazards were identified, and appropriate pre‐and post‐release mitigation strategies were identified and implemented, illustrating the direct conservation application and significance ...
Alice Bacon, Beatriz S. G. Alves, Simon Girling, Adam Naylor   +3 more
wiley   +1 more source

Feline Infectious Peritonitis (FIP) in Himalayan Cats at Hasanuddin University Educational Veterinary Clinic: Feline Infectious Peritonitis (FIP) in Himalayan Cats at Hasanuddin University Educational Veterinary Clinic

, 2022
Feline infectious peritonitis (FIP) is a viral disease, this disease can cause death in various types of cats but is not zoonotic. Feline infectious peritonitis (FIP) is caused by Feline corona virus (FCoV) from the family Coronaviridae, genus ...
Jamaluddin, Abdul Wahid, Sumule, Carisma, monica, waode santa, Musdalifah, Musdalifah   +3 more
core   +1 more source

Development of a New Indirect ELISA Test for the Detection of Anti-Feline Coronavirus Antibodies in Cats

Veterinary Sciences
Background/Objectives: Feline coronavirus (FCoV) belongs to the family Coronaviridae and includes two pathotypes, the less virulent feline enteric coronavirus (FECV), which replicates in the enteric epithelial cells, and feline infectious peritonitis ...
Irene Ferrero, Sarah Dewilde, Paolo Poletti, Barbara Canepa, Enrica Giachino, Paola Dall’Ara, Joel Filipe   +6 more
doaj   +1 more source

SEROLOGICAL AND MOLECULAR DIAGNOSIS OF FELINE INFECTIOUS PERITONITIS VIRUS IN CATS IN IRAQ [PDF]

Assiut Veterinary Medical Journal
Feline infectious peritonitis (FIP) is one of the most common infectious diseases that easily leads to death in young cats and other wild felines. This study aimed to investigate feline infectious peritonitis virus in cats brought to private veterinary ...
SAFWAN ALBAROODI, WASAN ALOBAIDII, MAAB AL-FARWACHI, DONEA ABDULLAH, FUFA GIMBA, SHOLA OLA-FADUNSIN   +5 more
doaj   +1 more source