Results 111 to 120 of about 16,301 (208)

Uridine prevents fenofibrate-induced fatty liver.

, 2014
Uridine, a pyrimidine nucleoside, can modulate liver lipid metabolism although its specific acting targets have not been identified. Using mice with fenofibrate-induced fatty liver as a model system, the effects of uridine on liver lipid metabolism are ...
Thuc T. Le (114801), Thuc T Le, Yasuyo Urasaki, Giuseppe Pizzorno (114815), Yasuyo Urasaki (114806), Giuseppe Pizzorno   +5 more
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Vascular endothelium as a target of beraprost sodium and fenofibrate for antiatherosclerotic therapy in type 2 diabetes mellitus

, 2005
Michio Otsuki, Kayoko Goya, Soji KasayamaDepartment of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, JapanAbstract: Diabetes mellitus is an important risk factor for cardiovascular morbidity and mortality.
Michio Otsuki, Soji Kasayama, Kayoko Goya   +2 more
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Fenofibrate promotes ischemia-induced revascularization through the adiponectin-dependent pathway

, 2010
Recent clinical trials demonstrated that PPARα agonist fenofibrate reduces cardiovascular events, including limb amputation in people with type 2 diabetes.
Noriyuki Ouchi, Rei Shibata, Ping Li, Megumi Kondo, Sonomi Maruyama, Koji Ohashi, Toyoaki Murohara   +6 more
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Role of fenofibrate in multiple sclerosis

Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the central nervous system (CNS). The underlying pathophysiology of MS is the destruction of myelin sheath by immune cells.
Ahmad A. Abulaban, Alexiou, Athanasios, Asma Alanazi, Abulaban, Ahmad A., Al-Gareeb, Ali I., Batiha, Gaber El-Saber, Al-kuraishy, Hayder M., Hayder M. Al-kuraishy, Athanasios Alexiou, Engy Elekhnawy, Papadakis, Marios, Marios Papadakis, Gaber El-Saber Batiha, Elekhnawy, Engy, Alanazi, Asma, Ali I. Al-Gareeb   +15 more
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Cardiometabolic benefits of fenofibrate in heart failure related to obesity and diabetes

Cardiovascular Diabetology
Background Heart failure (HF) is a serious and common condition affecting millions of people worldwide, with obesity being a major cause of metabolic disorders such as diabetes and cardiovascular disease.
Jiwon Park, Hangyul Song, Shinje Moon, Yumin Kim, Sungsoo Cho, Kyungdo Han, Cheol-Young Park, Sung Woo Cho, Chang-Myung Oh   +8 more
doaj   +1 more source

Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics

, 2009
Fenofibrate, widely used for the treatment of dyslipidemia, activates the nuclear receptor, peroxisome proliferator-activated receptor alpha. However, liver toxicity, including liver cancer, occurs in rodents treated with fibrate drugs.
Zhang, Xinying, Sun, He, Krausz, Kristopher W, Gonzalez, Frank J, Liu, Aiming, Liu, Wei, Idle, Jeffrey R, Patterson, Andrew D, Qiu, Fayang, Dai, Renke, Yang, Zongtao   +10 more
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Effect of fenofibrate on blood pressure reduction

, 2013
Реферат по материалам статей 1. Gilbert K, Nian H, Yu C, Luther JM, Brown NJ. Fenofibrate lowers blood pressure in salt-sensitive but not salt-resistant hypertension. J Hypertens. 2013 Apr;31(4):820-9. doi: 10.1097/HJH.0b013e32835e8227. 2. Kwang K.

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Fenofibrate for diabetic retinopathy

, 2019
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To investigate the effects of fenofibrate on the prevention and progression of diabetic retinopathy.
Watanabe, Norio, Kataoka, Sachiko Y., Inoue, Kana, Furukawa, Toshi A., Kawano, Sumihiro, Lois, Noemi   +5 more
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Fenofibrate targets PPARα-CPT1C axis to reverse aging by regulating lipid metabolism and mitochondrial function

Pharmacological Research
Aging poses a growing global health burden, creating an urgent need for effective interventions. This study reveals that fenofibrate, a clinically approved drug for hyperlipidemia, exerts significant anti-aging effects by targeting fundamental aging ...
Yanying Zhou, Yixin Chen, Linlin Zhu, Huilin Li, Yue Gao, Tu Xian, Pengfei Zhao, Shicheng Fan, Núria Casals, Min Huang, Huichang Bi   +10 more
doaj   +1 more source

PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice

, 2006
Peroxisome proliferator-activated receptor α (PPARα) is a member of the ligand-activated nuclear receptor superfamily, and plays an important role in lipid metabolism and glucose homeostasis.
Guan, Y, Breyer, M., Su, D., Su, D, Zheng, F, Davis, L., Zhang, Y., Chen, L, Striker, G, Breyer, M, Park, C.W., Cha, DR, Hwang, M.-T., Cha, D.R., Fan, X., Wu, J, Park, CW, Striker, G., Zhang, X., Wu, J., Zhang, Y, Zhang, X, Fan, X, Guan, Y., Davis, L, Chen, L., Hwang, MT, Zheng, F.   +27 more
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