Impact of concomitant fibrates on immunotherapy outcomes for advanced non‐small cell lung cancer [PDF]
Cancer Medicine, 2023 Background Peroxisome proliferator‐activated receptor agonists such as fibrates restore oxidative metabolism in cytotoxic T‐lymphocytes, thereby enhancing response to immune checkpoint inhibitors (ICI) in preclinical models. However, there is no evidence
William A. Stokes +11 more
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Current perspectives on lipid management in diabetic kidney disease: Can fibrates offer advantages over statins for renal outcomes? [PDF]
Journal of Research in Medical SciencesDiabetic kidney disease (DKD) affects 30%–40% of patients with diabetes mellitus (DM). Dyslipidemia is a key modifiable risk factor for the development and progression of DKD.
Mohammad Reza Chitsazi +9 more
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Cardiovascular Diabetology, 2004 Although less clinical intervention studies have been performed with fibrates than with statins, there are evidences indicating that fibrates may reduce risk of cardiovascular events. The potential clinical benefit of the fenofibrate will be specified by
Tenenbaum Alexander, Fisman Enrique Z
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Comparative efficacy and safety of ursodeoxycholic acid, fibrates, and combination therapy in primary biliary cholangitis: an umbrella meta-analysis of meta-analyses [PDF]
Frontiers in PharmacologyBackgroundPrimary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by progressive cholestasis. Although ursodeoxycholic acid (UDCA) is the standard therapy, a substantial proportion of patients show inadequate response ...
Jian Zhang, Ting Xiu, Qi Shen
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BMC Research NotesFibrates can prevent and treat ischemic stroke (IS), the occurrence and development of IS is closely related to hypoxia-inducible factor-1A (HIF-1A). However, the exact mechanism by which fibrates regulate HIF-1A to treat IS remains unclear.
Fengjiao Yang +8 more
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Fibrates for the Treatment of Primary Biliary Cholangitis Unresponsive to Ursodeoxycholic Acid: An Exploratory Study [PDF]
Frontiers in Pharmacology, 2022 Aim: Up to 40% of patients with primary biliary cholangitis (PBC) will have a suboptimal biochemical response to ursodeoxycholic acid (UDCA), which can be improved by the addition of fibrates.
Guilherme Grossi Lopes Cançado +23 more
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Lipid management in the prevention of stroke: a meta-analysis of fibrates for stroke prevention [PDF]
BMC Neurology, 2013 Background Fibrates has been extensively used to improve plasma lipid levels and prevent adverse cardiovascular outcomes. However, the effect of fibrates on stroke is unclear at the present time. We therefore carried out a comprehensive systematic review
Zhou Yu-Hao +6 more
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Disproportionality analysis of biliary adverse events associated with fibrates using the JADER and FAERS databases [PDF]
Frontiers in PharmacologyIntroductionFibrates are effective triglyceride-lowering drugs, but they may affect bile acid metabolism, raising concerns about biliary adverse drug events (ADEs).ObjectiveIn this study, we used spontaneous reporting system databases to evaluate the ...
Satoko Watanabe +6 more
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Reduced Muscle Loss in Patients With NSCLC Taking Fibrates: Findings From a Retrospective Observational Study [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground The cancer‐anorexia‐cachexia syndrome (CACS) is a common and debilitating wasting disorder characterized by loss of skeletal muscle and worse morbidity and mortality.
Rahmi Elahjji +9 more
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Milan Journal of Mathematics, 2022 AbstractWe review the theory of Lagrangian fibrations of hyperkähler manifolds as initiated by Matsushita. We also discuss more recent work of Shen–Yin and Harder–Li–Shen–Yin. Occasionally, we give alternative arguments and complement the discussion by additional observations.
D. Huybrechts, M. Mauri
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