Results 11 to 20 of about 14,825 (199)

Current perspectives on lipid management in diabetic kidney disease: Can fibrates offer advantages over statins for renal outcomes? [PDF]

Journal of Research in Medical Sciences
Diabetic kidney disease (DKD) affects 30%–40% of patients with diabetes mellitus (DM). Dyslipidemia is a key modifiable risk factor for the development and progression of DKD.
Mohammad Reza Chitsazi, Farzad Safari, Elena Malekpour, Seyed Arsham Mirzaei, Mohammad Hossein Shafieyoun, Faraz Golafshan, Hanieh Rouzbahani, Mohadese Nekookhoo, Ali Noursina, Mansour Siavash   +9 more
doaj   +3 more sources

Comparative efficacy and safety of ursodeoxycholic acid, fibrates, and combination therapy in primary biliary cholangitis: an umbrella meta-analysis of meta-analyses [PDF]

Frontiers in Pharmacology
BackgroundPrimary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by progressive cholestasis. Although ursodeoxycholic acid (UDCA) is the standard therapy, a substantial proportion of patients show inadequate response ...
Jian Zhang, Ting Xiu, Qi Shen
doaj   +2 more sources

Exploring the mechanism of fibrates regulating HIF-1A in the treatment of ischemic stroke based on network pharmacology and molecular docking

BMC Research Notes
Fibrates can prevent and treat ischemic stroke (IS), the occurrence and development of IS is closely related to hypoxia-inducible factor-1A (HIF-1A). However, the exact mechanism by which fibrates regulate HIF-1A to treat IS remains unclear.
Fengjiao Yang, Zixuan Yang, Ya Yan, Yun Gu, Pengyu Wang, Min Wang, Jianjie Chen, Xiaoshan Du, Guangming Wang   +8 more
doaj   +2 more sources

Lipid management in the prevention of stroke: a meta-analysis of fibrates for stroke prevention [PDF]

BMC Neurology, 2013
Background Fibrates has been extensively used to improve plasma lipid levels and prevent adverse cardiovascular outcomes. However, the effect of fibrates on stroke is unclear at the present time. We therefore carried out a comprehensive systematic review
Zhou Yu-Hao, Ye Xiao-Fei, Yu Fei-Fei, Zhang Xiao, Qin Ying-Yi, Lu Jian, He Jia   +6 more
doaj   +3 more sources

Fibrates for the Treatment of Primary Biliary Cholangitis Unresponsive to Ursodeoxycholic Acid: An Exploratory Study [PDF]

Frontiers in Pharmacology, 2022
Aim: Up to 40% of patients with primary biliary cholangitis (PBC) will have a suboptimal biochemical response to ursodeoxycholic acid (UDCA), which can be improved by the addition of fibrates.
Guilherme Grossi Lopes Cançado, Guilherme Grossi Lopes Cançado, Cláudia Alves Couto, Laura Vilar Guedes, Michelle Harriz Braga, Débora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado, Maria Lucia Gomes Ferraz, Cristiane Alves Villela-Nogueira, Mateus Jorge Nardelli, Luciana Costa Faria, Elze Maria Gomes de Oliveira, Vivian Rotman, Daniel Ferraz de Campos Mazo, Valéria Ferreira de Almeida e Borges, Valéria Ferreira de Almeida e Borges, Liliana Sampaio Costa Mendes, Liana Codes, Liana Codes, Mario Guimarães Pessoa, Izabelle Venturini Signorelli, Cynthia Levy, Paulo Lisboa Bittencourt, Paulo Lisboa Bittencourt   +23 more
doaj   +2 more sources

Lagrangian Fibrations

Milan Journal of Mathematics, 2022
AbstractWe review the theory of Lagrangian fibrations of hyperkähler manifolds as initiated by Matsushita. We also discuss more recent work of Shen–Yin and Harder–Li–Shen–Yin. Occasionally, we give alternative arguments and complement the discussion by additional observations.
D. Huybrechts, M. Mauri
openaire   +4 more sources

Latent Fibrations: Fibrations for Categories of Partial Maps

Theory and Applications of Categories, 2021
65 pages, submitted to "Theory and Applications of Categories"
Cockett, Robin, Cruttwell, Geoff, Gallagher, Jonathan, Pronk, Dorette   +3 more
openaire   +3 more sources

Obeticholic Acid and Fibrates in Primary Biliary Cholangitis: Comparative Effects in a Multicentric Observational Study

, 2021
INTRODUCTION: Obeticholic acid (OCA) and fibrates therapy results in biochemical improvement in placebo-controlled trials in patients with primary biliary cholangitis and insufficient response to ursodeoxycholic acid.
Albillos, Agustin, Perez-Medrano, Indhira, De la Cruz, Gema, Gomez-Camarero, Judith, Vargas, Victor, Morillas, Rosa M, Arencibia , Ana, Fernandez-Rodriguez, Conrado M, Hijona, Lander, Gonzalez-Santiago, Jesus M, Molina, Esther, Alvarez-Navascues, Carmen, Romero-Gómez, Manuel, Estevez, Pamela, Ferre-Aracil, Carlos, Parés, Albert, Gomez Dominguez , Elena, Reig, Anna, Casado, Marta, Gallego-Moya, Adolfo, Fábrega, Emilio, Vergara, Mercedes, Diago, Moises, Suarez, Francisco, Andrade, Raul J, Fernandez-Bonilla, , Eva, Sala, Margarita, Hernandez-Guerra, Manuel, Berenguer, Marina, Horta , Diana, Chahri, Nadia   +30 more
core   +2 more sources

The Gödel Fibration

, 2021
39 ...
Davide Trotta, Matteo Spadetto, Valeria de Paiva   +2 more
openaire   +4 more sources

Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression [PDF]

, 2009
In this study, we investigated the effects of statins, fibrates, 9-cis-retinoic acid and forskolin on the transcription of the mitochondrial carnitine/acylcarnitine carrier (CAC) gene.
Iacobazzi V, Palmieri F, Todisco S, Scarcia P, Infantino V, Convertini P   +5 more
core   +3 more sources