Results 21 to 30 of about 14,040 (225)
Peroxisome Proliferator-Activated Receptor Alpha Target Genes [PDF]
, 2010 The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.
Rakhshandehroo, M. +11 more
core +1 more source
Notre Dame Journal of Formal Logic, 2017 As far as we know no notion of concreteness for fibrations exists. We introduce such a notion and discuss some basic results about it.
openaire +4 more sources
Theory and Applications of Categories, 2022 This paper defines double fibrations (fibrations of double categories) and describes their key examples and properties. In particular, it shows how double fibrations relate to existing fibrational notions such as monoidal fibrations and discrete double fibrations, proves a representation theorem for double fibrations, and shows how double fibrations ...
Cruttwell, G. S. H. +3 more
openaire +3 more sources
CoRR, 2022 Deep Learning has significantly impacted the application of data-to-decision throughout research and industry, however, they lack a rigorous mathematical foundation, which creates situations where algorithmic results fail to be practically invertible. In this paper we present a nearly invertible mapping between $\mathbb{R}^{2^n}$ and $\mathbb{R}^{n+1}$
Daniel Livschitz, Weiqing Gu
openaire +2 more sources
, 2021 INTRODUCTION: Obeticholic acid (OCA) and fibrates therapy results in biochemical improvement in placebo-controlled trials in patients with primary biliary cholangitis and insufficient response to ursodeoxycholic acid.
Francisco Suárez +61 more
core +1 more source
Frontiers in Nutrition, 2022 Obesity is characterized by lipid accumulation in distinct organs. Presently, fenofibrate is a commonly used triglyceride-lowering drug. This study is designed to investigate whether long-term fenofibrate intervention can attenuate lipid accumulation in ...
Ying Zhang +6 more
doaj +1 more source
Fibrates and cholestasis [PDF]
Hepatology, 2015 Cholestasis, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), results from an impairment or disruption of bile production and causes intracellular retention of toxic bile constituents, including bile salts. If left untreated, cholestasis leads to liver fibrosis and cirrhosis, which eventually results in liver failure ...
Nisanne S, Ghonem +2 more
openaire +2 more sources
Journal of Mathematical Sciences, 2023 In this paper, we study equivariant Hurewicz fibrations, obtain their internal characteristics, and prove theorems on relationship between equivariant fibrations and fibrations generated by them. Local and global properties of equivariant fibrations are examined.
openaire +3 more sources
Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2
EMBO Molecular Medicine, 2014 Bacterial sepsis results in high mortality rates, and new therapeutics to control infection are urgently needed. Here, we investigate the therapeutic potential of fibrates in the treatment of bacterial sepsis and examine their effects on innate immunity.
Ivan Tancevski +19 more
doaj +1 more source
Fibrates: A Possible Treatment Option for Patients with Abdominal Aortic Aneurysm?
Biomolecules, 2022 Abdominal aortic aneurysm (AAA) is a life-threatening disease; however, there is no established treatment for patients with AAA. Fibrates are agonists of peroxisome proliferator-activated receptor alpha (PPARα) that are widely used as therapeutic agents ...
Naofumi Amioka, Toru Miyoshi
doaj +1 more source