Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study[S]
Journal of Lipid Research, 2010 Hypertriglyceridemia, defined as a triglyceride measurement > 150 mg/dl, occurs in up to 34% of adults. Fenofibrate is a commonly used drug to treat hypertriglyceridemia, but response to fenofibrate varies considerably among individuals.
Mary K. Wojczynski +8 more
doaj +1 more source
PPAR-α agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children in a randomized controlled trial [PDF]
, 2007 Article n.9 Open access : http://www.nutritionandmetabolism.com/content/4/1/9 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17451602International audienceBACKGROUND: Insulin resistance is often associated with increased levels ...
Asle Aarsland +11 more
core +3 more sources
Machine Learning‐Based Prediction of Drug‐Induced QTc Changes in a Large Finnish Biobank Cohort
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Prolongation of the QT interval is a known precursor to serious arrhythmias and sudden cardiac death, often triggered by medication use. Current medication risk evaluation platforms rely on literature‐based synthesis and may lag behind real‐world developments.
Ville Langén +7 more
wiley +1 more source
Regulation of genes involved in carnitine homeostasis by PPARa across different species (rat, mouse, pig, cattle, chicken, and human) [PDF]
, 2012 Recent studies in rodents convincingly demonstrated that PPAR-alpha is a key regulator of genes involved in carnitine homeostasis, which serves as a reasonable explanation for the phenomenon that energy deprivation and fibrate treatment, both of which ...
Egeri, Leonie +4 more
core +1 more source
Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]
, 2016 BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc +12 more
core +2 more sources
Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels. [PDF]
, 2018 Aldosterone is released from adrenal zona glomerulosa (ZG) cells and plays an important role in Na and K homoeostasis. Mutations in the human inwardly rectifying K channel CNJ type (KCNJ) 5 (KCNJ5) gene encoding the G-coupled inwardly rectifying K ...
Al Maskari, Raya +4 more
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Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future [PDF]
, 2019 Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies.
Corson, Timothy W., Park, Bomina
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International Journal of Nanomedicine, 2012 Kwang-Ho Cha,1,3 Kyung-Jin Cho,3 Min-Soo Kim,4 Jeong-Soo Kim,3 Hee Jun Park,1,3 Junsung Park,1,3 Wonkyung Cho,1,3 Jeong-Sook Park,3 Sung-Joo Hwang1,21Yonsei Institute of Pharmaceutical Sciences, 2College of Pharmacy, Yonsei University, Incheon, Republic ...
Cha KH +8 more
doaj
Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents [PDF]
, 2011 Background During the past decade, proprotein convertase subtilisin kexin type 9 (PCSK9) has been identified as a key regulator of serum LDL-cholesterol (LDL-C) levels.
Robert J Konrad +2 more
core +2 more sources
PPAR Research, 2011 Peroxisome proliferator-activated receptor-alpha (PPAR-α) activation by fenofibrate reduces blood pressure and sodium retention during DOCA-salt hypertension. PPAR-α activation reduces the expression of inflammatory cytokines, such as interleukin-6 (IL-
Dexter L. Lee +4 more
doaj +1 more source