Results 91 to 100 of about 16,301 (208)

Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro

PPAR Research, 2012
Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and atherosclerosis.
Zhou Zhou, Weiliang Sun, Ying Liang, Yanxiang Gao, Wei Kong, Youfei Guan, Juan Feng, Xian Wang   +7 more
doaj   +1 more source

Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation

, 2015
Abid Mehmood Yousaf,1 Dong Wuk Kim,1 Yu-Kyoung Oh,2 Chul Soon Yong,3 Jong Oh Kim,3 Han-Gon Choi11College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 2College of Pharmacy, Seoul National University, Seoul,
Oh YK, Yong CS, Kim DW, Kim JO, Choi HG, Yousaf AM   +5 more
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Fenofibrate and diabetic retinopathy

Background: Diabetic retinopathy (DR), a sight-threatening ocular complication of diabetes mellitus, is one of the main causes of blindness in the working-age population.
Karti , Omer, Osman Saatci , Ali, SAATCİ, ALİ OSMAN, KARTI, ÖMER   +3 more
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Fenofibrate increases neuronal vasoconstrictor response in mesenteric arteries from diabetic rats: Role of noradrenaline, neuronal nitric oxide and calcitonin gene-related peptide

, 2011
We evaluated the possible effects of long-term fenofibrate treatment on adrenergic, nitrergic and CGRP-ergic innervation function in mesenteric arteries from streptotozin-induced diabetic rats. We analysed the vasoconstrictor response to electrical field
Balfagón, Gloria, Lara del Campo, Gloria Balfagon, Del Campo Milán, Lara, Blanco Rivero, Javier, Javier Blanco-Rivero   +5 more
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Fenofibrate promoted triglyceride accumulation in HepG2 cells.

, 2014
(A-C) HepG2 cells were cultured in serum-starved medium with or without fenofibrate for 48 h: (A) cellular TG contents, (B) oil red O staining, and (C) electron micrographs showing the increased accumulation of lipid droplets (arrows) in the cytoplasm ...
Fang Yan (134746), Ling Gao (429702), Tingting Wang (123983), Chunxiao Yu (561760), Wenbin Chen (90534), Mingfeng Cao (577797), Jiajun Zhao (577798), Chao Xu (201376), Qi Wang (22418), Xiaoming Zhou (308488), Fei Jing (298892)   +10 more
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Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway

Acta Pharmaceutica Sinica B
Fenofibrate, a peroxisome proliferator-activated receptor α (PPARα) agonist, is widely prescribed for hyperlipidemia management. Recent studies also showed that it has therapeutic potential in various liver diseases.
Shicheng Fan, Yue Gao, Pengfei Zhao, Guomin Xie, Yanying Zhou, Xiao Yang, Xuan Li, Shuaishuai Zhang, Frank J. Gonzalez, Aijuan Qu, Min Huang, Huichang Bi   +11 more
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Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study[S]

Journal of Lipid Research, 2010
Hypertriglyceridemia, defined as a triglyceride measurement > 150 mg/dl, occurs in up to 34% of adults. Fenofibrate is a commonly used drug to treat hypertriglyceridemia, but response to fenofibrate varies considerably among individuals.
Mary K. Wojczynski, Guimin Gao, Ingrid Borecki, Paul N. Hopkins, Laurence Parnell, Chao-Qiang Lai, Jose M. Ordovas, B. Hong Chung, Donna K. Arnett   +8 more
doaj   +1 more source

Novel fenofibrate derivatives as cannabinoid receptor ligands [PDF]

, 2011
Fenofibrate is a PPARα agonist, used to treat dyslipidemia. Unpublished work that has been previously carried out in our group has identified that fenofibrate also displays affinity for the cannabinoid receptors, CB1 and CB2. A dual receptor ligand, with
Spencer, Sarah Jane
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Fenofibrate protects against JEV infection, in vivo, in mice.

, 2013
(A) Fenofibrate markedly reduced the mortality in JEV infected animals (n = 15 per group). (B) Scores depicting the reversal of behavioral deficits following fenofibrate treatment compared to JEV infection alone (n = 15 per group ...
Kanhaiya Lal Kumawat (102188), Anirban Basu (102199), Neha Sehgal (326548), Vijayalakshmi Ravindranath (49675)   +3 more
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Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study [PDF]

, 2014
Aims/hypothesis In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n=9795), fenofibrate reduced major cardiovascular events in type 2 diabetes.
d'Emden, Michael C., Keech, Anthony C, Li, Liping, Zannino, Diana, Saltevo, Juha, D'Emden, Michael C, Stuckey, Bronwyn GA, on behalf of the FIELD Study Investigators, Best, James D., Jenkins, Alicia J, Jenkins, Alicia J., Park, Kris, Mann, Kristy P, Stuckey, Bronwyn G. A., Keech, Anthony C., Best, James D, Mann, Kristy P.   +16 more
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