Results 11 to 20 of about 29,324 (231)

Comparison of efficacy and safety of choline fenofibrate (fenofibric acid) to micronized fenofibrate in patients of mixed dyslipidemia: A randomized, open-label, multicenter clinical trial in Indian population

Indian Journal of Endocrinology and Metabolism, 2016
Introduction: Choline fenofibrate is a newly developed choline salt of fenofibric acid, which is more hydrophilic than fenofibrate. This study was initiated to evaluate the safety and efficacy of choline fenofibrate in comparison to micronized ...
Piyush Patel, Hanmant Barkate
doaj   +1 more source

Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat [PDF]

, 2017
UCP2 maps nearby the lod score peak of STR1-stroke QTL in the SHRSP rat strain. We explored the potential contribution of UCP2 to the high-salt diet (JD)-dependent increased stroke susceptibility of SHRSP.
Baima, Simona, Bianchi, Franca, Cotugno, Maria, D'Esposito, Maurizio, Fioriniello, Salvatore, Forte, Maurizio, Gelosa, Paolo, Madonna, Michele, Marchitti, Simona, Morelli, Giorgio, Ragione, Floriana Della, Rubattu, Speranza Donatella, Sciarretta, Sebastiano, Sironi, Luigi, Stanzione, Rosita, Volpe, Massimo   +15 more
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Fenofibrate diminishes the self-renewal and metastasis potentials of oral carcinoma stem cells through NF-κB signaling

Journal of the Formosan Medical Association, 2022
Background/Purpose: NF-κB family of transcription factors are the major contributors to malignant tumor progression, maintenance of cancer stemness, and enhancement of chemoresistance.
Tzu-Rong Su, Cheng-Chia Yu, Shih-Chi Chao, Chun-Chung Huang, Yi-Wen Liao, Pei-Ling Hsieh, Chuan-Hang Yu, Shih-Shen Lin   +7 more
doaj   +1 more source

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice [PDF]

, 2009
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment.
A Chroni, A Duka, A Patsialou, A Rigotti, A Walsh, AP Feinberg, B Staels, B Staels, B Staels, B Staels, B Staels, B Staels, BN Finck, CW Miller, D Arsenijevic, D Lan, D Sanoudou, D Sanoudou, D Sanoudou, EM Rubin, ES Cathcart, F Yadetie, G Fredrikson, G Martin, H Duez, H Samyn, HB Rubins, HY Kan, J Karbowska, J Lin, J St Pierre, JC Fruchart, JD Brunzell, JJ Lehman, JK Reddy, JL Goldstein, JM Huss, JM Huss, JP Desager, K C Hayes, K Drosatos, K Motojima, K Schoonjans, K Schoonjans, KE Kypreos, KE Kypreos, KS Frederiksen, L Berthou, LA Pennacchio, LJ Kelly, M Bouly, MB Eisen, MC Hunt, MJ Holness, N Hennuyer, N Vu-Dac, N Vu-Dac, N Vu-Dac, N Vu-Dac, NF Cariello, P Puigserver, Q Guo, R Sladek, RB Vega, RL Jacobs, SA Greenberg, SN Schreiber, V Beisvag, V Giguere, V I Zannis, V Litvak, VG Tusher, VI Zannis, VI Zannis, VI Zannis, WC Roberts, X Prieur, Y Kamei, Y Nagai, Z Wu   +79 more
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Fenofibrate improves vascular endothelial function and contractility in diabetic mice

Redox Biology, 2019
Fenofibrate, a peroxisome proliferator-activated receptors α (PPARα) agonist, reduces vascular complications of diabetic patients but its protective mechanisms are not fully understood.
Nan Xu, Qin Wang, Shan Jiang, Qijing Wang, Weipeng Hu, Suhan Zhou, Liang Zhao, Lanyu Xie, Jianghua Chen, Anton Wellstein, En Yin Lai   +10 more
doaj   +1 more source

Effect of diet-induced obesity on protein expression in insulin signalling pathways of skeletal muscle in male Wistar rats [PDF]

, 2012
BACKGROUND: The prevalence of diet-induced obesity is increasing globally, and posing significant health problems for millions of people worldwide. Diet-induced obesity is a major contributor to the global pandemic of type 2 diabetes mellitus.
Abubakari, Abdul-Razak, Fatani, Sameer, Itua, Imose, Naderali, Ebrahim K., Thomas, Cecil, Wong, Christopher   +5 more
core   +2 more sources

Therapeutic Effects of Fenofibrate Nano-Emulsion Eye Drops on Retinal Vascular Leakage and Neovascularization

Biology, 2021
Macular edema caused by retinal vascular leakage and ocular neovascularization are the leading causes of severe vision loss in diabetic retinopathy (DR) and age-related macular degeneration (AMD) patients.
Li Huang, Wentao Liang, Kelu Zhou, Ronald A. Wassel, Zachary D. Ridge, Jian-Xing Ma, Bing Wang   +6 more
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Automation potential of a new, rapid, microscopy based method for screening drug-polymer solubility [PDF]

, 2020
For the pharmaceutical industry, the preformulation screening of the compatibility of drug and polymeric excipients can often be time-consuming because of the use of trial-and-error approaches.
Alhijjaj, Muqdad, Belton, Peter, Fabian, Laszlo, Qi, Sheng, Reading, Mike   +4 more
core   +1 more source

Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression

Journal of Lipid Research, 2007
In addition to efficiently decreasing VLDL-triglycerides (TGs), fenofibrate increases HDL-cholesterol levels in humans. We investigated whether the fenofibrate-induced increase in HDL-cholesterol is dependent on the expression of the cholesteryl ester ...
Caroline C. van der Hoogt, Willeke de Haan, Marit Westerterp, Menno Hoekstra, Geesje M. Dallinga-Thie, Johannes A. Romijn, Hans M.G. Princen, J. Wouter Jukema, Louis M. Havekes, Patrick C.N. Rensen   +9 more
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Effect of fenofibrate and atorvastatin on VLDL apoE metabolism in men with the metabolic syndrome

Journal of Lipid Research, 2012
We examined the effects of fenofibrate and atorvastatin on very low density lipoprotein (VLDL) apolipoprotein (apo)E metabolism in the metabolic syndrome (MetS). We studied 11 MetS men in a randomized, double-blind, crossover trial.
Esther M.M. Ooi, Theodore W.K. Ng, Gerald F. Watts, Dick C. Chan, P. Hugh R. Barrett   +4 more
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