Results 41 to 50 of about 13,138 (168)
Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho +9 more
wiley +2 more sources
Assessment of fenofibrate-methylation interactions on triglycerides using longitudinal family data
BMC Proceedings, 2018 Background Triglyceride (TG) concentrations decrease in response to fenofibrate treatment, and also are associated with DNA methylation. But how interactions between fenofibrate response and DNA methylation affect TGs remains unclear.
Jih-Chang Yu +2 more
doaj +1 more source
Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025
Movement Disorders, EarlyView.Abstract Background In the past decade, significant advances have improved our understanding of the mechanisms underlying HD pathobiology leading to several putative therapeutic targets for HD. Objective The aim was to describe the Huntington's disease (HD) drug development clinical pipeline.
Pavlina Konstantinova +5 more
wiley +1 more source
Scientific Reports, 2021 Endothelial progenitor cells (EPCs) improve endothelial impairment, which in turn restores endothelial function in patients with heart failure (HF).
Wen-Pin Huang +5 more
doaj +1 more source
Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis
Portal Hypertension &Cirrhosis, EarlyView.Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao +4 more
wiley +1 more source
Indian Journal of Endocrinology and MetabolismIntroduction: Fenofibrate forms the standard of care for managing hypertriglyceridemia. Many of these patients have associated metabolic dysfunction-associated steatotic liver disease (MASLD). No systematic review and meta-analysis (SRM) has analysed the
Manoj Kumar +4 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Subretinal fibrosis is a common pathological change that causes vision loss in neovascular age-related macular degeneration (nAMD). Treatment modalities for subretinal fibrosis are limited.
Qian Chen +11 more
doaj +1 more source
Smart Molecules, EarlyView.A green and simple photo‐oxygenation of benzylic C‐H bond with molecular oxygen was developed for the preparation of a series of carbonyl compounds. The straightforward C‐H carbonylation strategy features catalyst‐ and additive‐free reaction conditions, only oxygen as a green oxidant, broad scope and scalable, and the simple‐operation nature.
Jianing Li +6 more
wiley +1 more source
Fenofibrate improves renal lipotoxicity through activation of AMPK-PGC-1α in db/db mice. [PDF]
PLoS ONE, 2014 Peroxisome proliferator-activated receptor (PPAR)-α, a lipid-sensing transcriptional factor, serves an important role in lipotoxicity. We evaluated whether fenofibrate has a renoprotective effect by ameliorating lipotoxicity in the kidney. Eight-week-old
Yu Ah Hong +13 more
doaj +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.Among 200 patients with primary sclerosing cholangitis, 38% reported moderate to severe pruritus in the past 6 months. During 6 months of follow up, pruritus severity fluctuated significantly. Pruritus severity was linked to worse colitis activity and lower quality of life.
Richard Dean +16 more
wiley +1 more source