Results 51 to 60 of about 16,301 (208)
Frontiers in Behavioral Neuroscience, 2017 We have previously shown that the administration of fenofibrate to high-drinker UChB rats markedly reduces voluntary ethanol intake. Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPARα) agonist, which induces the proliferation of ...
Mario Rivera-Meza +7 more
doaj +1 more source
Fenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease
Drug Design, Development and Therapy, 2023 Chao Tang,1,2,* Xiaoqing Deng,1,* Jingru Qu,1 Yahui Miao,1 Lei Tian,1 Man Zhang,1 Xiaoyu Li,1 Bei Sun,1 Liming Chen1 1NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital ...
Tang C +8 more
doaj
Molecular docking of fenofibrate with proteins of hub genes.
, 2022 (A). The binding poses of ESR1 complexed with fenofibrate. (B). The binding poses of JUN complexed with fenofibrate. (C). The binding poses of UBE2I complexed with fenofibrate. Hydrogen bonds are indicated as dashed lines.
Yun Chen (279569) +5 more
core +1 more source
Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025
Movement Disorders, EarlyView.Abstract Background In the past decade, significant advances have improved our understanding of the mechanisms underlying HD pathobiology leading to several putative therapeutic targets for HD. Objective The aim was to describe the Huntington's disease (HD) drug development clinical pipeline.
Pavlina Konstantinova +5 more
wiley +1 more source
Fenofibrate for Diabetic Retinopathy
, 2018 Fenofibrate is a safe and inexpensive orally administered fibric acid derivative conventionally used to treat dyslipidemia. Two large randomized clinical trials, the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) and the Action to ...
Stewart, Stephen, Lois, Noemi
core +1 more source
Assessment of fenofibrate-methylation interactions on triglycerides using longitudinal family data
BMC Proceedings, 2018 Background Triglyceride (TG) concentrations decrease in response to fenofibrate treatment, and also are associated with DNA methylation. But how interactions between fenofibrate response and DNA methylation affect TGs remains unclear.
Jih-Chang Yu +2 more
doaj +1 more source
Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis
Portal Hypertension &Cirrhosis, EarlyView.Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao +4 more
wiley +1 more source
Smart Molecules, EarlyView.A green and simple photo‐oxygenation of benzylic C‐H bond with molecular oxygen was developed for the preparation of a series of carbonyl compounds. The straightforward C‐H carbonylation strategy features catalyst‐ and additive‐free reaction conditions, only oxygen as a green oxidant, broad scope and scalable, and the simple‐operation nature.
Jianing Li +6 more
wiley +1 more source
Crystallization of undercooled liquid fenofibrate [PDF]
Formulation of hydrophobic drugs as amorphous materials is highly advantageous as this increases their solubility in water and therefore their bioavailability.
Amstad, Esther +2 more
core +1 more source
Indian Journal of Endocrinology and MetabolismIntroduction: Fenofibrate forms the standard of care for managing hypertriglyceridemia. Many of these patients have associated metabolic dysfunction-associated steatotic liver disease (MASLD). No systematic review and meta-analysis (SRM) has analysed the
Manoj Kumar +4 more
doaj +1 more source