Results 61 to 70 of about 13,138 (168)

Successful Management of Hypertriglyceridemia‐Induced Acute Pancreatitis in Resource‐Limited Setting: A Case Report and Brief Review of the Literature

open access: yesClinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT A 44‐year‐old man presented with acute abdominal pain and was diagnosed with hypertriglyceridemia‐induced acute pancreatitis. He was managed with fluid resuscitation, analgesia, and insulin infusion and had good recovery. Recognizing hypertriglyceridemia as an etiology of acute pancreatitis and insulin infusion as a treatment modality is ...
Mukti Nath Sankhi   +5 more
wiley   +1 more source

Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential

open access: yesTranslational Oncology, 2019
Anticancer effects of a common lipid-lowering drug, fenofibrate, have been described in the literature for a quite some time; however, fenofibrate has not been used as a direct anticancer therapy.
J. Stalinska   +15 more
doaj   +1 more source

Iron‐Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol‐Related Lipid Metabolic Diseases

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Alcohol metabolism induces structural instability of iron‐sulfur clusters through ROS‐mediated oxidative damage and direct covalent modification of acetaldehyde. The iron‐sulfur cluster deficiency drives metabolic reprogramming by inactivating aconitase, accumulating succinate, and impairing tRNA thiolation, thereby promoting hepatic steatosis ...
Li Xu   +6 more
wiley   +1 more source

Multicomponent Analysis of Antihyperlipidemic Drugs: Integrating Analytical Quality by Design and Multi‐Metric Green Liquid Chromatography

open access: yesSEPARATION SCIENCE PLUS, Volume 9, Issue 9, September 2026.
Robust HPLC method quantifies four antihyperlipidemic drugs. Central composite design optimized the analytical conditions. Achieved complete isocratic separation in under 10 min. Multiple green metrics confirmed excellent environmental sustainability. Validated method successfully analyzed commercial binary formulations.
Venkatesh Bukkapatnam, Raja Sundararajan
wiley   +1 more source

Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro

open access: yesPPAR Research, 2012
Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and atherosclerosis.
Zhou Zhou   +7 more
doaj   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

open access: yesActa Ophthalmologica, Volume 104, Issue 6, Page e630-e647, September 2026.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen   +3 more
wiley   +1 more source

Enhancement of the dissolution rate and bioavailability of fenofibrate by a melt-adsorption method using supercritical carbon dioxide

open access: yesInternational Journal of Nanomedicine, 2012
Kwang-Ho Cha,1,3 Kyung-Jin Cho,3 Min-Soo Kim,4 Jeong-Soo Kim,3 Hee Jun Park,1,3 Junsung Park,1,3 Wonkyung Cho,1,3 Jeong-Sook Park,3 Sung-Joo Hwang1,21Yonsei Institute of Pharmaceutical Sciences, 2College of Pharmacy, Yonsei University, Incheon, Republic ...
Cha KH   +8 more
doaj  

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

open access: yesJournal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2623-2638, September 2026.
ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive course to cirrhosis and hepatic decompensation, at which point liver ...
Simone I. Strasser   +6 more
wiley   +1 more source

Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway

open access: yesActa Pharmaceutica Sinica B
Fenofibrate, a peroxisome proliferator-activated receptor α (PPARα) agonist, is widely prescribed for hyperlipidemia management. Recent studies also showed that it has therapeutic potential in various liver diseases.
Shicheng Fan   +11 more
doaj   +1 more source

Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study[S]

open access: yesJournal of Lipid Research, 2010
Hypertriglyceridemia, defined as a triglyceride measurement > 150 mg/dl, occurs in up to 34% of adults. Fenofibrate is a commonly used drug to treat hypertriglyceridemia, but response to fenofibrate varies considerably among individuals.
Mary K. Wojczynski   +8 more
doaj   +1 more source

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