Results 11 to 20 of about 16,301 (208)

Fenofibrate improves vascular endothelial function and contractility in diabetic mice

Redox Biology, 2019
Fenofibrate, a peroxisome proliferator-activated receptors α (PPARα) agonist, reduces vascular complications of diabetic patients but its protective mechanisms are not fully understood.
Qijing Wang, Suhan Zhou, Jianghua Chen   +2 more
exaly   +4 more sources

Fenofibrate as an anti-cancer treatment: an in vitro study on glioblastoma cells at various oxygen levels and on normal astrocytes [PDF]

Cancer Cell International
Fenofibrate, an active pharmaceutical ingredient (API) of the fibrate class approved by the U.S. Food and Drug Administration (FDA) for the treatment of hypercholesterolemia and hyperlipidemia, has emerged as a promising candidate for repurposing in ...
Yasmine Chokry, Anne-Claire Groo, Sophie Corvaisier, Ons Ben Hadj Hassen, Isis Blanchard, Samuel Valable, Aurélie Malzert-Fréon   +6 more
doaj   +2 more sources

Effects of fenofibrate on angiopoietin-like 3/4/8 proteins and apolipoprotein A5 [PDF]

Journal of Lipid Research
Fenofibrate and other fibrates are peroxisome proliferator–activated receptor alpha agonists that are used to lower plasma triglyceride (TG) levels. Although fibrates are effective in decreasing TG, their ability to reduce adverse cardiovascular events ...
Ye Yang, Sydney Smith, Yan Q. Chen, Hongxia Li, Eugene Y. Zhen, John H. Sloan, Robert W. Siegel, Yuewei Qian, Yi Wen, Hyesoo Jung, Julia L. Scheithauer, Sander Kersten, Stephen G. Young, Robert J. Konrad   +13 more
doaj   +2 more sources

Comparison of efficacy and safety of choline fenofibrate (fenofibric acid) to micronized fenofibrate in patients of mixed dyslipidemia: A randomized, open-label, multicenter clinical trial in Indian population

Indian Journal of Endocrinology and Metabolism, 2016
Introduction: Choline fenofibrate is a newly developed choline salt of fenofibric acid, which is more hydrophilic than fenofibrate. This study was initiated to evaluate the safety and efficacy of choline fenofibrate in comparison to micronized ...
Piyush Patel, Hanmant Barkate
doaj   +2 more sources

Pleiotropic Effects of Fenofibrate

Current Pharmaceutical Design, 2009
Fenofibrate represents the most commonly used fibric acid derivative. The drug exerts its metabolic effects by modulating the expression of several genes involved in lipoprotein metabolism. In addition, numerous studies suggest that fenofibrate may also affect the progression of the atherosclerotic process by several lipid-independent mechanisms.
Tsimihodimos, V., Liberopoulos, E., Elisaf, M. S.   +2 more
openaire   +4 more sources

Enhancement of the dissolution rate and bioavailability of fenofibrate by a melt-adsorption method using supercritical carbon dioxide

International Journal of Nanomedicine, 2012
Kwang-Ho Cha,1,3 Kyung-Jin Cho,3 Min-Soo Kim,4 Jeong-Soo Kim,3 Hee Jun Park,1,3 Junsung Park,1,3 Wonkyung Cho,1,3 Jeong-Sook Park,3 Sung-Joo Hwang1,21Yonsei Institute of Pharmaceutical Sciences, 2College of Pharmacy, Yonsei University, Incheon, Republic ...
Cha KH, Cho KJ, Kim MS, Kim JS, Park HJ, Park J, Cho W, Park JS, Hwang SJ   +8 more
doaj   +1 more source

Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential

Translational Oncology, 2019
Anticancer effects of a common lipid-lowering drug, fenofibrate, have been described in the literature for a quite some time; however, fenofibrate has not been used as a direct anticancer therapy.
J. Stalinska, E. Zimolag, NA. Pianovich, A. Zapata, A. Lassak, M. Rak, M. Dean, D. Ucar-Bilyeu, D. Wyczechowska, F. Culicchia, L. Marrero, L. Del Valle, J. Sarkaria, F. Peruzzi, BS Jursic, K. Reiss   +15 more
doaj   +3 more sources

Fenofibrate enhances lipid deposition via modulating PPARγ, SREBP-1c, and gut microbiota in ob/ob mice fed a high-fat diet

Frontiers in Nutrition, 2022
Obesity is characterized by lipid accumulation in distinct organs. Presently, fenofibrate is a commonly used triglyceride-lowering drug. This study is designed to investigate whether long-term fenofibrate intervention can attenuate lipid accumulation in ...
Ying Zhang, Xiu-Bin Jia, Yun-Chao Liu, Wen-Qian Yu, Yan-Hong Si, Yan-Hong Si, Shou-Dong Guo   +6 more
doaj   +1 more source

Long-Term Fenofibrate Treatment Stimulates the Phenotypic Microevolution of Prostate Cancer Cells In Vitro

Pharmaceuticals, 2022
Fenofibrate is a widely used anti-hyperlipidemic agonist of peroxisome proliferator-activated receptor alpha (PPARα). As a metabolic blocker, fenofibrate interferes with cancer promotion/progression via its misbalancing effects on cellular metabolism ...
Karolina W. Warzecha, Maciej Pudełek, Jessica Catapano, Zbigniew Madeja, Jarosław Czyż   +4 more
doaj   +1 more source

Fenofibrate for the prevention of progression of non-proliferative diabetic retinopathy: review, consensus recommendations and guidance for clinical practice [PDF]

International Journal of Ophthalmology, 2022
The prevalence of diabetic retinopathy (DR), and associated morbidity is high in the Asia-Pacific region. Emerging evidence suggests a potential role for fenofibrate in the prevention of progression of DR, especially in patients with cardiovascular risk,
Nor Fariza Ngah, Nor Asiah Muhamad, Roslin Azni Abdul Aziz, Shelina Oli Mohamed, Nor Azita Ahmad Tarmizi, Azian Adnan, Zalifah Zakiah Asnir, Zanariah Hussein, Hui Foo Siew, Masni Mohamed, Noor Aliza Lodz, Vijayamala Valayatham   +11 more
doaj   +1 more source