Results 51 to 60 of about 12,682 (143)
Cell Proliferation, EarlyView.This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang +10 more
wiley +1 more source
Fenofibrate improves renal lipotoxicity through activation of AMPK-PGC-1α in db/db mice. [PDF]
PLoS ONE, 2014 Peroxisome proliferator-activated receptor (PPAR)-α, a lipid-sensing transcriptional factor, serves an important role in lipotoxicity. We evaluated whether fenofibrate has a renoprotective effect by ameliorating lipotoxicity in the kidney. Eight-week-old
Yu Ah Hong +13 more
doaj +1 more source
Impaired Adipose Anabolism in Pancreatic Cancer Cachexia Is Reversed by HuR Inhibition
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.ABSTRACT Background Cachexia is defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC) and negatively impacts patient outcomes. Nutritional supplementation cannot fully reverse tissue wasting, and the mechanisms underlying this phenotype are unclear.
Paige C. Arneson‐Wissink +10 more
wiley +1 more source
Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy
Advanced Science, Volume 13, Issue 16, 18 March 2026.Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro +6 more
wiley +1 more source
Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential
Translational Oncology, 2019 Anticancer effects of a common lipid-lowering drug, fenofibrate, have been described in the literature for a quite some time; however, fenofibrate has not been used as a direct anticancer therapy.
J. Stalinska +15 more
doaj +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, Volume 13, Issue 14, 9 March 2026.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Fenofibrate protects endothelial cells against the harmful effects of TNF-alpha
SA Heart Journal, 2017 Introduction: Fenofibrate exerts pleiotropic effects on endothelial cells (ECs) by, amongst others, increasing nitric oxide (NO) production. We aimed to investigate fenofi brate’s putative beneficial actions in healthy or TNF-alpha-induced dysfunctional ...
Westcott, Corli +6 more
doaj +1 more source
Eruptive Xanthomas in a Patient With Severe Dyslipidemia
JEADV Clinical Practice, EarlyView.
Michał Niedźwiedź +3 more
wiley +1 more source
Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard +2 more
wiley +1 more source
Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro
PPAR Research, 2012 Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and atherosclerosis.
Zhou Zhou +7 more
doaj +1 more source