Results 1 to 10 of about 195,889 (397)

Naloxone reversal of the cardiorespiratory depressant effects of opioids and mixtures of opioids and stimulants in rats [PDF]

Frontiers in Pharmacology
Co-use of opioids (e.g., fentanyl) and stimulants (e.g., methamphetamine; METH) contributed to >30% of the almost 106,000 fatal overdoses in the United States in 2023.
Jacqueline M. Vazquez, Robert W. Seaman, Drew Caldron, Gregory T. Collins, Gregory T. Collins   +4 more
doaj   +2 more sources

A humanized monoclonal antibody attenuates carfentanil self-administration in nonhuman primates [PDF]

Drug and Alcohol Dependence Reports
Approximately 70 % of fatal drug overdoses in the United States are attributed to fentanyl and fentanyl analogs. Current medications for reversing overdose and treating opioid use disorder might not be as effective against fentanyl and fentanyl analogs ...
Lindsey K. Galbo-Thomma, Carly Baehr, Elaine A. Gay, Scott Runyon, Marco Pravetoni, Charles P. France   +5 more
doaj   +2 more sources

Abuse potential of fentanyl and fentanyl analogues [PDF]

BioImpacts
Introduction: In this perspective review, we evaluated the clinical management of fatal fentanyl overdose in several routes of administration, concentrating on both legally prescribed and illegally produced formulations. Methods: A literature search was
Anusha Thumma, Kwadwo Mfoafo, Niloofar Babanejad, Alborz Omidian, Yadollah Omidi, Hamid Omidian   +5 more
doaj   +3 more sources

Suicide by Fentanyl [PDF]

Toxicology Letters, 2006
Suicide by FentanylFentanyl is a potent, short-acting narcotic analgesic widely used as surgical anaesthetic. This article presents a case in which fentanyl was self-injected by a 41-year old nurse, an employee at the hospital emergency department, who was found dead at home. She had no known history of drug and alcohol abuse.
Marija Definis-Gojanović, Davorka Sutlović   +1 more
openaire   +7 more sources

Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid receptor-dependent activation of EGFR

BMC Anesthesiology, 2022
Background Fentanyl is an opioid analgesic and is widely used in ovarian cancer patients for pain management. Although increasing evidence has suggested the direct role of fentanyl on cancer, little is known on the effect of fentanyl on ovarian cancer ...
Kai Xiao, Qinghong Zheng, Lei Bao
doaj   +1 more source

Assessment of two brands of fentanyl test strips with 251 synthetic opioids reveals “blind spots” in detection capabilities

Harm Reduction Journal, 2023
Background Fentanyl test strips (FTS) are a commonly deployed tool in drug checking, used to test for the presence of fentanyl in street drug samples prior to consumption.
Kathleen L. Hayes, Marya Lieberman
doaj   +1 more source

Mass Spectral Character of Fentanyl Analogues [PDF]

Fayixue Zazhi, 2019
Objective To provide the reference for the identification of unknown fentanyl analogues by studying the characteristic ions and main fragmentation pathways of fentanyl analogues in the modes of collision induced dissociation （CID） and electron ionization
YAN Jin, HUA Zhen-dong, JIA Wei, et al.
doaj   +1 more source

Effects of neonatal fentanyl on late adolescent opioid-mediated behavior

Frontiers in Neuroscience, 2023
IntroductionBecause of the steady increase in the use of synthetic opioids in women of childbearing age, a large number of children are at risk of exposure to these drugs prenatally or postnatally through breast milk.
Cynthia A. Crawford, Jordan A. Taylor, Ginny I. Park, Jasmine W. Rios, Joseph Bunch, Constance J. Greenwood, David Y. Lopez Sanchez, Diego J. Gonzales   +7 more
doaj   +1 more source

A comprehensive evaluation of the potential binding poses of fentanyl and its analogs at the µ-opioid receptor

Computational and Structural Biotechnology Journal, 2022
Fentanyl and its analogs are selective agonists of the µ-opioid receptor (MOR). Among novel synthetic opioids (NSOs), they dominate the recreational drug market and are the main culprits for the opioid crisis, which has been exacerbated by the COVID-19 ...
Bing Xie, Alexander Goldberg, Lei Shi
doaj   +1 more source

Perbandingan Efektivitas Kombinasi Fentanyl–Paracetamol dan Fentanyl–Ketorolac terhadap Numerical Rating Scale (NRS) Post Operasi Seksio Sesarea

Jurnal Anestesi Obstetri Indonesia, 2020
Latar Belakang: Nyeri post operasi seksio sesarea merupakan nyeri sedang berat dengan intensitas akut. Saat ini terdapat dua kombinasi obat anti nyeri yang umum digunakan untuk mengatasi nyeri post operasi seksio sesarea yaitu kombinasi parasetamol ...
Andy H, Sugeng Budi Santoso, RTH Supraptomo   +2 more
doaj   +1 more source