Advanced Science, EarlyView.A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du +18 more
wiley +1 more source
A review of dominant lactic acid bacteria strains and inoculation fermentation for fermented mustard plant. [PDF]
Front MicrobiolZhou Y +9 more
europepmc +1 more source
Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration
Advanced Science, EarlyView.Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman +5 more
wiley +1 more source
Ultrasound-assisted fermentation of buttermilk by <i>Limosilactobacillus fermentum</i> and <i>Lacticaseibacillus rhamnosus</i>: Effects on bacterial proliferation, antioxidant potential, and enzymatic inhibition. [PDF]
Curr Res Food SciHashemi SMB, Gholamhosseinpour A.
europepmc +1 more source
A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat
Advanced Science, EarlyView.An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su +10 more
wiley +1 more source
An Amazonian Ganoderma isolate as a source of antioxidant proteins: Influence of submerged fermentation conditions on mycelial architecture and bioactivity. [PDF]
Braz J MicrobiolPessoa VA +7 more
europepmc +1 more source
Advanced Science, EarlyView.TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang +17 more
wiley +1 more source
The regulatory role of histidine kinase in modulating nucleoside metabolites in <i>Streptomyces noursei</i> CK-15. [PDF]
Front MicrobiolLiao Y, Xie J, Zhao Q, Yu H, Ge B.
europepmc +1 more source
Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, EarlyView.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source