Results 201 to 210 of about 2,690,812 (395)

RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy

open access: yesAdvanced Science, EarlyView.
RAB3B is unveiled as a prominent oncogenic regulator in chordoma, which can block the DUSP12‐mediated dephosphorylation of p‐S6 (S235/236). The combination of RAB3B and p‐S6 indicates a good prognostic value and predicts mTORC1 inhibitors response for chordoma patients.
Jianxuan Gao   +15 more
wiley   +1 more source

Time‐resolved multiparameter analytics on a cell‐free production platform for acyl‐CoA precursors

open access: yesAnalytical Science Advances, Volume 3, Issue 11-12, Page 289-296, December 2022., 2022
Abstract Cell‐free biosynthesis is emerging as a very attractive alternative for the production of market‐relevant molecules. The free combination of enzymes, regardless of where they are isolated from, raises the possibility to build more efficient synthetic routes but at the same time leads to higher complexity regarding the analysis of the different
Dominic Maehler   +7 more
wiley   +1 more source

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

open access: yesAdvanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma   +13 more
wiley   +1 more source

Jet cooking dramatically improves the wet strength of soy adhesives

open access: yesJournal of the American Oil Chemists' Society, Volume 100, Issue 1, Page 69-79, January 2023., 2023
Abstract The impact of jet cooking on shear strength of soy‐and‐water adhesives was investigated to understand the higher shear strength of commercial soy protein isolates compared to soy flours. Soy flour‐based wood adhesives are appealing because of their bio‐based content, low formaldehyde emission, and low cost, but their commercial application is ...
Christopher G. Hunt   +6 more
wiley   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

open access: yesAdvanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang   +12 more
wiley   +1 more source

Fermentation Processes Using Lactic Acid Bacteria Producing Bacteriocins for Preservation and Improving Functional Properties of Food Products

open access: hybrid, 2012
Gražina Juodeikienė   +5 more
openalex   +1 more source

The Transcription Factor WFZP Interacts with the Chromatin Remodeler TaSYD to Regulate Root Architecture and Nitrogen Uptake Efficiency in Wheat

open access: yesAdvanced Science, EarlyView.
Root development and nitrogen uptake efficiency are vital for crop productivity. Du, Li, Jiang, et al. show that the wheat transcription factor WFZP and the chromatin remodeler TaSYD form a complex within the nucleus, thereby activating the expression of genes associated with root development and nitrate transporters, ultimately enhancing both root ...
Dejie Du   +18 more
wiley   +1 more source

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