Results 161 to 170 of about 2,478,172 (300)

Hierarchical Flux‐Protection Engineering Stabilizes Oxidation‐Prone Metabolic Nodes for High‐Level Curcumin Biosynthesis

Advanced Science, EarlyView.
Flux‐protection engineering stabilizes an oxidation‐prone L‐DOPA node in engineered E. coli by combining acid‐adapted chassis evolution, respiratory‐chain modulation, enzyme‐level flux matching, and pH–DO control. Carbon is redirected from oxidative browning to productive biosynthesis, enabling 1075.2 mg/L curcumin and demonstrating transferability to ...
Jianbin Chen, Qihang Chen, Shurong Zhang, Yajuan Su, Xiaoyi Zou, Ke Wang, Shike Liu, Qian He, Liang Zhang, Weizhu Zeng, Jingwen Zhou   +10 more
wiley   +1 more source

Hybrid Metal–Organic Framework‐Derived Dual Active Site Catalysts Enabling Surface‐Enriched Cathode and Modified Zinc Anode for Long‐Life Zinc–Air Batteries

Advanced Science, EarlyView.
This work demonstrates the implementation of MOF‐assisted anode and cathode materials for prolonged cycling of zinc‐air batteries with strong redox capability and structural stability. ABSTRACT The surface modification of zinc anodes and the development of effective cathode dual‐functional oxygen electrocatalysts remain of paramount interest for ...
Ramasamy Santhosh Kumar, Duraisami Kaviyarasu, Dilmurod Sayfiddinov, Murugavel Kathiresan, Pandian Mannu, Chung‐Li Dong, Arul Manuel Stephan, Dong Jin Yoo   +7 more
wiley   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Optimization and impact of sludge alkaline fermentation on nutrient removal from sewage

, 2014
Optimization and impact of sludge alkaline fermentation on nutrient removal from ...
Katsou, Evangelia, FATONE, Francesco, Malamis, Symeon Alexandros, D. Renzi, LONGO, STEFANO, FRISON, Nicola   +5 more
core   +1 more source

Synthetic Shewanella‐Bacillus Microbial Consortia for Enhanced Metal Oxide Leaching From Spent Lithium‐Ion Batteries Using Brewing Wastewater as Leaching Agent

Advanced Science, EarlyView.
A recycling approach of spent lithium‐ion batteries is developed using brewing wastewater as the leaching agent and an engineering microbial consortium as the biocatalyst. Shewanella oneidensis reduces spent LiNixCoyMn1‐x‐yO2 cathodes via extracellular electron transfer, while Bacillus subtilis removes residual ethanol to eliminate inhibition.
Baocai Zhang, Chunxiao Qiao, Huichun Liu, Yiyun Wang, Yan Liu, Huan Yu, Junqi Zhang, Chao Li, Deguang Wu, Qulai Tang, Zhiwen Wang, Danni Zhang, Dake Xu, Feng Li, Hao Song   +14 more
wiley   +1 more source

Enhancing acetate-based biosurfactant production by Pseudomonas putida KT2440 through fermentation optimization. [PDF]

Microb Cell Fact
Michel CV, Weike C, Breuer LN, Hampe LAI, Schneider M, Franciò G, Leitner W, Tiso T, Blank LM.   +8 more
europepmc   +1 more source

Interactive Evolutionary Computation for Model based Optimization of Batch Fermentation

, 2003
At the optimization of temperature and feeding profiles of batch processes it is often desirable to consider several objectives and constraints into the optimization problem.
Janos Madar, Balazs Balasko, Ferenc Szeifert, Janos Abonyi   +3 more
core  

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

Production improvement of dalbavancin precursor A40926B0 in <i>Nonomuraea gerenzanensis</i> through strain reconstruction and fermentation optimization. [PDF]

Synth Syst Biotechnol
Liu XY, Liu YQ, Zheng YL, Ruan JY, Fang P, Fang JL, Chen XA, Zhao QW, Lyu ZY, Li YQ.   +9 more
europepmc   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source