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Optimal control of a semibatch fermentation
Biotechnology and Bioengineering, 1976AbstractThis work is concerned with the optimization study of the semibatch fermentation by which an amino acid is produced. The particular fermentation studied is the synthesis of lysine by the auxotrophic mutant. Applying Green's theorem to the maximization problem was proposed, and it succeeded in determining the feed rate of the substrate that ...
H, Ohno, E, Nakanishi, T, Takamatsu
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Optimal control of a fermentation process
2003 European Control Conference (ECC), 2003This paper includes the description of a batch beer fermentation process that has been optimised using a technique based on the application of calculus of variations. The gradient method in function space is thus introduced as a valuable tool for the optimal control of the beer fermentation process selected.
Carillo-Ureta, G. E. +2 more
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Optimization of whey fermentation in a shaken-flask fermenter
European Journal of Applied Microbiology and Biotechnology, 1979A composite design technique was used to optimize the fermentation of whey by Kluyveromyces fragilis IMAT 1872. The experimental variables (temperature T, salts NP, yeast-extract YE and lactose level L), but not pH, were found to be significant at a level of 5%. The optimal operating conditions were determined (T=36.4°C, pH=5.1, NP=0.47% w/v, YE=0.114%
Mauro Moresi, Enzo Sebastiani
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Fermentation Process Control and Optimization
Chemical Engineering & Technology, 2022AbstractProcess control and optimization is important in ensuring a process in sustaining profitable income while maintaining the required quality. The fermentation process has attracted attention from food processing, pharmaceutical energy, and waste treatment industries due to its lower impact on the environment and lower operating cost than the ...
Wan Ying Chai +3 more
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Optimal fermentation time for Nigrospora‐fermented tea rich in bostrycin
Journal of the Science of Food and Agriculture, 2020AbstractBACKGROUNDBostrycin has many biological functions, such as anticancer activity, and is becoming increasingly popular. Nigrospora sphaerica HCH285, which has the ability to produce high levels of bostrycin, can be used to ferment sun‐dried green tea of Camellia sinensis through acclimation, resulting in the development of a Nigrospora‐fermented ...
Jinhan Li +8 more
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Optimization of fermentation conditions for alcohol production
Biotechnology and Bioengineering, 1984AbstractThe quantitative effects of carbohydrate levels, degree of initial saccharification, glucoamylase dosage, temperature, and fermentation time were investigated using a Box–Wilson central composite design protocol. With Saccharomyces cerevisiae ATCC 4126, it was found that the use of a partially saccharified starch substrate markedly increased ...
L, Bowman, E, Geiger
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Feedback optimization of fed‐batch fermentation
Biotechnology and Bioengineering, 1987AbstractThe problem of feedback optimization of the feed rate for fed‐batch fermentation processes is formulated in the framework of singular control theory and switching hypersurfaces. Using four differential balance equations that describe a general class of fedbatch processes and a general objective function to be minimized, it is shown that under ...
J M, Modak, H C, Lim
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Optimizing scale-up fermentation processes
Trends in Biotechnology, 2002There are many aims associated with the optimization of fermentation processes. Optimization is expected to increase the yield of the final product but the process must be compliant with good manufacturing practices, the available equipment and the expected final scale of operation.
Michel, Thiry, Doriano, Cingolani
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Modeling and optimization of fermentative hydrogen production
Bioresource Technology, 2011Biohydrogen is a sustainable energy resource due to its potentially higher efficiency of conversion to usable power, non-polluting nature and high energy density. The purpose of modeling and optimization is to improve, analyze and predict biohydrogen production.
Kaushik, Nath, Debabrata, Das
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Optimization of Fermentation Conditions for the Production of Bacteriocin Fermentate""
2015Abstract : This report summarizes research to evaluate novel techniques to improve preservation of and to incorporate those best approaches to improve quality and stability of combat operational rations. The objectives were to optimize the production of bacteriocins (BAC), i.e., nisin and pediocin, using various unusual food-grade substrates (e.g. whey,
Claire Lee, Wayne Muller, Anthony Sikes
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