Results 11 to 20 of about 194,437 (305)
Chemistry and Biology of Ferritin
Metallomics, 2021 Iron is an essential element required by cells and has been described as a key player in ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming multimeric assemblies with crystalline iron cores.
M. Plays, S. Müller, Raphaël Rodriguez
semanticscholar +1 more source
Ferritin‐based drug delivery system for tumor therapy
BMEMat, 2023 Ferritin has been widely used in drug delivery in recent years due to its unique spherical nanocage structure. In addition, the natural targeting and good biocompatibility of ferritin make it an excellent drug delivery system.
Zaiqian Tu +3 more
doaj +1 more source
Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis
Circulation Research, 2020 Supplemental Digital Content is available in the text. Rationale: Maintaining iron homeostasis is essential for proper cardiac function. Both iron deficiency and iron overload are associated with cardiomyopathy and heart failure via complex mechanisms ...
X. Fang +17 more
semanticscholar +1 more source
The Role of Ferritin in Health and Disease: Recent Advances and Understandings
Metabolites, 2022 Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc.
N. Kotla +3 more
semanticscholar +1 more source
Ferritin – from iron, through inflammation and autoimmunity, to COVID-19
Journal of Autoimmunity, 2021 While it took decades to arrive to a conclusion that ferritin is more than an indicator of iron storage level, it took a short period of time through the COVID-19 pandemic to wonder what the reason behind high levels of ferritin in patients with severe ...
Naim Mahroum +6 more
semanticscholar +1 more source
the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. [PDF]
PLoS Pathogens, 2008 Iron sequestration by host iron-binding proteins is an important mechanism of resistance to microbial infections. Inside oral epithelial cells, iron is stored within ferritin, and is therefore not usually accessible to pathogenic microbes.
Ricardo S Almeida +7 more
doaj +1 more source
Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
Journal of clinical laboratory analysis (Print), 2020 The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients.
Linlin Cheng +6 more
semanticscholar +1 more source
Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis
Redox Biology, 2020 Cellular iron, at the physiological level, is essential to maintain several metabolic pathways, while an excess of free iron may cause oxidative damage and/or provoke cell death. Consequently, iron homeostasis has to be tightly controlled.
D. Fuhrmann +4 more
semanticscholar +1 more source
Ferritin – a multifaceted protein scaffold for biotherapeutics
Experimental and Molecular Medicine, 2022 The ferritin nanocage is an endogenous protein that exists in almost all mammals. Its hollow spherical structure that naturally stores iron ions has been diversely exploited by researchers in biotherapeutics.
Na-Kyeong Lee, Seongeon Cho, Insun Kim
semanticscholar +1 more source
Journal of critical care, 2021 Ferritin is a known inflammatory biomarker in COVID-19. However, many factors and co-morbidities can confound the level of serum ferritin. This current metaanalysis evaluates serum ferritin level in different severity levels in COVID-19.
Karanvir Kaushal +17 more
semanticscholar +1 more source