Results 51 to 60 of about 10,617 (280)

Haemophagocytic lymphohistiocytosis in kidney transplant recipients

Iatreia, 2019
Hemophagocytic lymphohistiocytosis (HLH) in renal transplant recipients is a life-threatening hyper-inflammatory syndrome; associated with uncontrolled activation of cytotoxic T-lymphocytes and macrophages due to infections or immunosuppressive therapy ...
Nieto Ríos, John Fredy, Morales Contreras, Carol Lisbeth, Chacón Jaimes, Diana Carolina, Benavides Henao, Diego Armando, Bello Márquez, Diana Carolina, Serna Higuita, Lina María   +5 more
doaj   +1 more source

Pulmonary Haemosiderosis Secondary to Hereditary Haemochromatosis; a Case Report

Journal of Cancer and Allied Specialties, 2020
Introduction: Hereditary haemochromatosis (HH) is an autosomal recessive disease of increased intestinal absorption of iron, leading to accumulation in tissues which may progress to organ damage, most commonly in the liver.
Waqas Jehangir, Alexander Karabachev, Elvira Umyarova   +2 more
doaj   +1 more source

Iron acquisition in Bacillus cereus: the roles of IlsA and bacillibactin in exogenous ferritin iron mobilization [PDF]

, 2015
9siIn host-pathogen interactions, the struggle for iron may have major consequences on the outcome of the disease. To overcome the low solubility and bio-availability of iron, bacteria have evolved multiple systems to acquire iron from various sources ...
Abi Khalil Elise, Arosio Paolo, Bou-Abdallah Fadi, Buisson Christophe, Daou Nadine, Kallassy Mireille, Lereclus Didier, Nielsen Le Roux Christina, Segond Diego   +8 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Exploring deep phylogenies using protein structure : a dissertation submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry, Institute of Natural and Mathematical Sciences, Massey University, Auckland, New Zealand [PDF]

, 2018
Recent times have seen an exponential growth in protein sequence and structure data. The most popular way of characterising newly determined protein sequences is to compare them to well characterised sequences and predict the function of novel sequences ...
Malik, Ashar J
core  

The Functionality of the three-sited Ferroxidase center of E. coli Bacterial Ferritin (EcFtnA) [PDF]

, 2014
At least three ferritins are found in the bacterium Escherichia coli, the heme-containing bacterioferritin (EcBFR) and two non-heme bacterial ferritins (EcFtnA and EcFtnB).
A. Awomolo, Andrews S. C., B. Cooper, Baaghil S., Bauminger E. R., Bauminger E. R., Bellapadrona G., Bou-Abdallah F., Bou-Abdallah F., Bou-Abdallah F., Bou-Abdallah F., Bou-Abdallah F., Bou-Abdallah F., Bou-Abdallah F., Bou-Abdallah F., Bou-Abdallah F., Bou-Abdallah F., Bunker J., Chasteen N. D., Chasteen N. D., Chen-Barrett Y., Cho K. J., Crow A., Ebrahim K. H., Ebrahimi K. H., Ebrahimi K. H., F. Bou-Abdallah, Fetter J., Grady J. K., Grady J. K., H. Yang, Harrison P. M., Harrison P. M., Jameson G. N. L., Johnson E., Lawson T. L., Le Brun N. E., Liu X., Lowery T. J., M. R. Woodhall, Masuda T., Masuda T., Moenne-Loccoz P., N. D. Chasteen, Pereira A. S., Pereira A. S., Pereira A. S., S. C. Andrews, Santambrogio P., Stillman T. J., Stillman T. J., Su M., Sun S., Sun S., Svistunenko D. A., Tatur J., Theil E. C., Treffry A., Treffry A., Treffry A., Wiedenheft B., Xu B., Yang X., Yang X., Zhang H., Zhao G., Zhao G., Zhao G., Zhao G., Zhao Z.   +69 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Hyperferritinaemia-cataract syndrome: Worldwide mutations and phenotype of an increasingly diagnosed genetic disorder [PDF]

, 2010
The hereditary hyperferritinaemia-cataract syndrome (HHCS) is characterised by an autosomal dominant cataract and high levels of serum ferritin without iron overload. The cataract develops due to L-ferritin deposits in the lens and its pulverulent aspect
Millonig, Gunda, Muckenthaler, Martina U., Mueller, Sebastian   +2 more
core   +2 more sources

Marked Long‐term Improvement in Lung Function in Melanoma Differentiation‐associated Protein 5 (MDA5) Antibody Positive Dermatomyositis Patients: Experience of a Single Center Longitudinal Cohort in North America

Arthritis Care &Research, Accepted Article.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation‐associated gene 5 antibody (MDA5 ab) associated dermatomyositis (DM). Methods Thirty patients with MDA5 ab DM were identified in a single center longitudinal cohort of 352 patients with ...
Jenice X Cheah, Sangmee S Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source