Results 71 to 80 of about 87,796 (384)

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

A case of hemophagocytic lymphohistiocytosis caused by an Epstein-Barr virus infection, presenting with unremitting fever and rash [PDF]

Pediatric Emergency Medicine Journal, 2019
Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by excessive activation of lymphocytes and macrophages, leading to cytokine storm.
Seong-Beom Oh, Chan-Young Koh
doaj   +1 more source

Antitumoral Efficacy of AuNRs‐Laden ECFCs In Vitro and In Vivo: Decoding the Heat and Rays Combo Treatment in Breast Cancer and Melanoma Cells

Advanced Healthcare Materials, EarlyView.
Endothelial Colony Forming Cells (ECFCs) acted as cellular cyborgs, stealthily transporting gold nanorods (AuNRs) into tumors to enable targeted near‐infrared (NIR) hyperthermia combined with radiotherapy. This approach triggers ferroptosis in melanoma and inhibits autophagy in breast cancer, revealing a tumor‐specific response to nanomaterial‐assisted
Cecilia Anceschi, Francesca Scavone, Paolo Armanetti, Luca Menichetti, Claudia Catarinicchia, Claudia Borri, Fulvio Ratto, Filippo Micheletti, Noemi Formica, Jessica Ruzzolini, Elena Frediani, Anastasia Chillà, Francesca Margheri, Mirko Severi, Rita Traversi, Patrizia Nardini, Daniele Guasti, Mario Del Rosso, Tommaso Del Rosso, Lisa Giovanelli, Cinzia Talamonti, Monica Mangoni, Isacco Desideri, Silvia Burchielli, Fabiola Pajar, Gabriella Fibbi, Anna Laurenzana   +26 more
wiley   +1 more source

Exploring deep phylogenies using protein structure : a dissertation submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry, Institute of Natural and Mathematical Sciences, Massey University, Auckland, New Zealand [PDF]

, 2018
Recent times have seen an exponential growth in protein sequence and structure data. The most popular way of characterising newly determined protein sequences is to compare them to well characterised sequences and predict the function of novel sequences ...
Malik, Ashar J
core  

Iron acquisition in Bacillus cereus: the roles of IlsA and bacillibactin in exogenous ferritin iron mobilization [PDF]

, 2015
9siIn host-pathogen interactions, the struggle for iron may have major consequences on the outcome of the disease. To overcome the low solubility and bio-availability of iron, bacteria have evolved multiple systems to acquire iron from various sources ...
Abi Khalil Elise, Arosio Paolo, Bou-Abdallah Fadi, Buisson Christophe, Daou Nadine, Kallassy Mireille, Lereclus Didier, Nielsen Le Roux Christina, Segond Diego   +8 more
core   +1 more source

Spatial Coordination Structure‐Driven Enzyme‐Like Selectivity in Single‐Atom Nanozymes

Advanced Materials, EarlyView.
Sun et al. reviews recent progress in enhancing the enzyme‐like catalytic selectivity of SAzymes through the rational design of their spatial coordination structures. They emphasize the structure‐activity relationships of various attributes of these coordination structures in promoting selective catalytic behavior, the strategic design of coordination ...
Qijun Sun, Si Liu, Ziping Li, Peiji Deng, Na Niu, Ligang Chen, Kang Liang   +6 more
wiley   +1 more source

Isolation and partial characterization of two porcine spleen ferritin fractions with different electrophoretic mobility [PDF]

, 1996
Ferritin isolated from porcine spleen could routinely be separated in two fractions on nondenaturating gradient gels. Both fractions could be isolated with a purity of 96% when applied to two serially linked columns, each 200 cm in length, packed ...
Cleton-Soeteman, M.I. (Maud), Eijk, H.G. (Henk) van, Huijskes-Heins, M.I.E. (M. I E), Klepper, D. (D.), Noort, W.L. (W.) van, Van Gelder, C.M. (Carin)   +5 more
core   +1 more source

Ferritins control interaction between iron homeostasis and oxidative stress in Arabidopsis.

The Plant Journal, 2009
Ferritin protein nanocages are the main iron store in mammals. They have been predicted to fulfil the same function in plants but direct evidence was lacking. To address this, a loss-of-function approach was developed in Arabidopsis.
Karl Ravet, B. Touraine, Jossia Boucherez, J. Briat, F. Gaymard, F. Cellier   +5 more
semanticscholar   +1 more source

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

Pulmonary Haemosiderosis Secondary to Hereditary Haemochromatosis; a Case Report

Journal of Cancer and Allied Specialties, 2020
Introduction: Hereditary haemochromatosis (HH) is an autosomal recessive disease of increased intestinal absorption of iron, leading to accumulation in tissues which may progress to organ damage, most commonly in the liver.
Waqas Jehangir, Alexander Karabachev, Elvira Umyarova   +2 more
doaj   +1 more source