Results 81 to 90 of about 81,213 (316)

The inverse correlation between serum levels of anti-pneumococcal and ferritin after pneumococcal vaccination in splenectomised beta thalassemia major

VacciMonitor, 2022
Splenectomy is necessary in beta thalassemia major patients when the spleen becomes hyperactive, leading to extreme destruction of erythrocytes. This study assessed the ferritin effect on serum pneumococcal antibody response following pneumococcal ...
Karamatollah Rahmanian, Masihollah Shakeri, Vahid Rahmanian, Shahryiar Najafi-Tireh Shabankareh, Fatemeh Sotoodeh Jahromi, Abdolreza Sotoodeh Jahromi   +5 more
doaj  

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Structural insights into the ferroxidase site of ferritins from higher eukaryotes

Journal of the American Chemical Society, 2012
The first step of iron biomineralization mediated by ferritin is the oxidation at the ferroxidase active site of two ferrous ions to a diferric oxo/hydroxo species. Metal-loaded ferritin crystals obtained by soaking crystals of frog ferritin in FeSO4 and
I. Bertini, D. Lalli, S. Mangani, C. Pozzi, C. Rosa, Elizabeth C. Theil, P. Turano   +6 more
semanticscholar   +1 more source

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

Mechanisms of Iron Oxidation in the Ferroxidase Centre of Escherichia coli Bacterioferritin: A Comparison to Other Ferritins [PDF]

, 2020
Ferritins are iron storage proteins that are both widespread and abundant in nature, being an essential means of solubilising and storing iron in a non-toxic manner for most organisms.
Pullin, Jacob
core   +3 more sources

Association between Serum Ferritin Levels and Diabetes Mellitus in a Korean Population

Korean Journal of Clinical Laboratory Science
Several studies have suggested that increased iron storage may promote the development of diabetes mellitus (DM). This study examined the association between the serum ferritin levels and DM in a Korean population. The study population consisted of 8,991
Jun Ho LEE
doaj   +1 more source

Size-dependent structural evolution of the biomineralized iron-core nanoparticles in ferritins

, 2013
The structural identity of the biomineralized iron core nanoparticles in Helicobacter pylori ferritins (Hpf's) has been determined by employing soft x-ray absorption spectroscopy and soft x-ray magnetic circular dichroism.
Eunsook Lee, D. Kim, Jihoon Hwang, Ki-Ho Lee, Sungwon Yoon, B. Suh, Kyung Hyun Kim, Jung-yup Kim, Z. Jang, Bongjae Kim, B. Min, J. Kang   +11 more
semanticscholar   +1 more source

β-Thalassaemia/haemoglobin E tissue ferritins

, 1990
Ferritins from liver and spleen of both β-thalassaemia/haemoglobin E (HbE) and non-thalassaemic patients were purified by heating a methanol-treated homogenate, followed by molecular exclusion chromatography.
Macey, D.J., Tran, K.C., Yansukon, P., Webb, J., Pootrakul, P.   +4 more
core  

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Serum Ferritin as a Predictor of Hospital Mortality in Critically Ill COVID-19 Patients

COVID
Serum ferritin levels increase in severe COVID-19 patients. However, few data correlating the sensitivity and specificity of ferritin levels and mortality prediction in COVID-19 exist. The current study aims to investigate the sensitivity and specificity
Ferhat Soykan, Demet Bolukbasi, Erol Toy, Nazan Has Selmi, Asiye Yavuz, Behiye Deniz Kosovali, Nevzat Mehmet Mutlu, Aliye Bastug, Derya Gokcinar, Belgin Akan, Seval Izdes   +10 more
doaj   +1 more source