Results 81 to 90 of about 10,712 (297)

Engineering Ferritin Nanoparticles for Theranostic Probes Development [PDF]

, 2016
疾病的诊断治疗学在近年来得到了巨大关注和广泛研究，以蛋白质为基础的纳米材料具有优异生物相容性、生物降解性、灵活的可修饰性等特点，在癌症的诊疗一体化研究上发挥着巨大作用。鉴于发展以蛋白质为核心的新型诊疗一体化探针具有重要的可应用和临床转化意义，我们在本论文中研究设计了多种以铁蛋白为核心的纳米材料，并着重探究了各种材料在诊疗一体化中的应用。主要内容概括如下： 第一章，我们简要介绍了肿瘤诊断治疗技术的发展和现状，着重探讨了肿瘤诊断治疗一体化的研究现状 ...
王占通
core  

Natural supramolecular protein assemblies [PDF]

, 2016
Supramolecular protein assemblies are an emerging area within the chemical sciences, which combine the topological structures of the field of supramolecular chemistry and the state-of-the-art chemical biology approaches to unravel the formation and ...
Mecinović, Jasmin, Nolte, Roeland J. M., Pieters, Bas J. G. E., van Eldijk, Mark B.   +3 more
core   +2 more sources

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

Genetic relationships of some Citrus genotypes based on the candidate iron chlorosis genes [PDF]

, 2014
Iron is one of the most important elements in plant mineral nutrition. Fe deficiency is a critical abiotic stress factor for Mediterranean citriculture; the development of marker-assisted selection for this trait would greatly enhance rootstock breeding.
Aka Kacar, Yildiz, Boncuk, Melda, Dönmez, Dicle, Ollitrault, Patrick, Simsek, Özhan, Yesiloglu, Turgut   +5 more
core   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity [PDF]

, 2014
15noMitochondrial ferritin is a functional ferritin that localizes in themitochondria.Itisexpressedinthetestis, heart,brain,and cells with active respiratory activity. Its overexpression in culturedcellsprotectedagainstoxidativedamageandreduced cytosolic
Dario Finazzi, Elena Donetti, Elena Gammella, Emilia Turco, Federica Maccarinelli, Fiorella Altruda, Gaetano Cairo, Giorgio Biasiotto, Laura Cornaghi, Maria Regoni, Maura Poli, Michela Asperti, Paolo Arosio, Silvia Lonardi, Stefania Recalcati   +14 more
core   +1 more source

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

Aqueous solution dispersement of carbon nanotubes [PDF]

, 2011
Carbon nanotubes (CNTs) are dispersed in an aqueous buffer solution consisting of at least 50 weight percent water and a remainder weight percent that includes a buffer material.
Choi, Sang H., Harrison, Joycelyn S., Kim, Jae-Woo, Lillehei, Peter T., Park, Cheol   +4 more
core   +1 more source

Tyr25, Tyr58 and Trp133 of Escherichia coli bacterioferritin transfer electrons between iron in the central cavity and the ferroxidase centre [PDF]

, 2017
Ferritins are 24meric proteins that overcome problems of toxicity, insolubility and poor bioavailability of iron in all types of cells by storing it in the form of a ferric mineral within their central cavities.
Abdul-Tehrani, Andrews, Andrews, Baaghil, Bauminger, Bou-Abdallah, Bradley, Bradley, Bradley, Bradley, Chaplin, Cheesman, Crow, Dimitri A. Svistunenko, Eshelman, Geoffrey R. Moore, Harrison, Hingorani, Hudson, Ito, Justin M. Bradley, Kwak, Laufberger, Lawson, Le Brun, Le Brun, Le Brun, Minnihan, Nick E. Le Brun, Pagba, Rajagopal, Reeder, Stiefel, Svistunenko, Theil, Thompson, Turano, Umena, Weeratunga, Weeratunga, Wong, Yang, Yasmin   +42 more
core   +2 more sources