Results 101 to 110 of about 81,213 (316)

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Correlation of Serum Ferritin Level with Severity of Neurological Disability in Acute Ischemic Stroke – A Cross-sectional Study

Biomedical and Biotechnology Research Journal
Background: Stroke continues to be a major cause of death and disability worldwide, with ischemic stroke forming most of the cases. Early identification of reliable biomarkers can help in predicting severity and improving outcomes.
Naved Chaudhari, Vivek Pande, Arvind Agrawal, Kartik Khurana   +3 more
doaj   +1 more source

Valores de ferritina sérica em beta talassemia heterozigota Serum ferritin levels in beta thalassemia carrier

Revista Brasileira de Hematologia e Hemoterapia, 2010
A low iron level, the commonest nutritional deficiency in the world, is a public health problem in developing countries. On the other hand, an excessive amount of iron is toxic, causing several organic dysfunctions, such as diabetes, cirrhosis ...
Isabeth F. Estevão, Maria Cristina S. Souza, Antonio J. Manzato, Claudia R. Bonini-Domingos   +3 more
doaj   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

[Tissue and blood ferritins and isoferritins]

, 1986
International audienceFerritins which can store excess iron are localised principally in tissue. Ferritins have on apoprotein shell which is composed of 24 sub-units, from 2 types of sub-units: "H" (molecular weight about 21 000) and "L" (molecular ...
Lasne, Y., Vernet, Marc, Collombel, C., Damour, O., Dellamonica, C.   +4 more
core   +2 more sources

Haemophagocytic lymphohistiocytosis in kidney transplant recipients

Iatreia, 2019
Hemophagocytic lymphohistiocytosis (HLH) in renal transplant recipients is a life-threatening hyper-inflammatory syndrome; associated with uncontrolled activation of cytotoxic T-lymphocytes and macrophages due to infections or immunosuppressive therapy ...
Nieto Ríos, John Fredy, Morales Contreras, Carol Lisbeth, Chacón Jaimes, Diana Carolina, Benavides Henao, Diego Armando, Bello Márquez, Diana Carolina, Serna Higuita, Lina María   +5 more
doaj   +1 more source

The Presence and Percentage of Circulating Nucleated Red Blood Cells Reveal Distinct Characteristics in Adults With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco, Ivan Lerner, Auria Godard, Luc Darnige, Laure Joseph, Wassim El Nemer, Geoffrey Cheminet, Jean‐Benoit Arlet   +7 more
wiley   +1 more source

β-Thalassaemia/haemoglobin E tissue ferritins - II: A comparison of heart and pancreas ferritins with those of liver and spleen

, 1990
Tissue ferritins from β-thalassaemia/haemoglobin E heart and pancreas were characterized by native PAGE, SDS/PAGE and isoelectric focussing, and compared with those isolated from corresponding liver and spleen tissue.
Macey, D.J., Tran, K.C., Webb, J., Pootrakul, P.   +3 more
core  

Safety and Feasibility of Magnetic Separation‐Based Blood Purification

Advanced NanoBiomed Research, EarlyView.
We present the preclinical biological safety and translational feasibility of a magnetic nanoparticle‐based extracorporeal blood purification platform for removal of disease‐causing blood factors. ISO 10993‐compliant studies and exaggerated worst‐case exposure models demonstrate efficient nanoparticle extraction (≥99.9%), favorable biocompatibility ...
Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaelle Clermont, Florian Dingreville, Chandrashekara Vishwanath, Rajesh Karunanithi, Alexander Gogos, Jean‐Claude Metzger, Manuel Baumgartner, Joerg C. Schefold, Inge K. Herrmann   +11 more
wiley   +1 more source

Role of molecular charge in glomerular permeability. Tracer studies with cationized ferritins

Journal of Cell Biology, 1975
Mouse kidneys were perfused with Krebs-Ringer bicarbonate buffer (KRB) containing native, anionic horse spleen ferritin or various cationized derivatives, and the glomerular localization of the probe molecules determined by electron microscopy. Ferritins
H. Rennke, R. Cotran, M. Venkatachalam
semanticscholar   +1 more source