Results 91 to 100 of about 7,994 (300)

Intra- and inter-subunit interactions in Mtb BfrB structure and relative conservation among representative ferritins.

, 2013
+/++/+++: Variable/Average/High conservation; CMyco: conserved in mycobacterial ferritins;*: The listed distances are as observed in (intra- or inter-) subunit A of Mtb BfrB.
Vibha Gupta (44479), Garima Khare (212371), Prachi Nangpal (353421), Rakesh K. Gupta (255910), Anil K. Tyagi (21905), Nicholas K. Sauter (353422)   +5 more
core   +1 more source

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, EarlyView.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

Association between Serum Ferritin Levels and Diabetes Mellitus in a Korean Population

Korean Journal of Clinical Laboratory Science
Several studies have suggested that increased iron storage may promote the development of diabetes mellitus (DM). This study examined the association between the serum ferritin levels and DM in a Korean population. The study population consisted of 8,991
Jun Ho LEE
doaj   +1 more source

Electrochemically Controlled Reconstitution of Immobilized Ferritins for Bioelectronic Applications

, 2007
Site-specific reconstituted nanoparticles were fabricated via electrochemically-controlled biomineralization through the immobilization of biomolecules.
Chu, Sang-Hong, King, Glen C., Watt, Gerald D., Kim, Jae-Woo, Choi, Sang H., Lillehei, Peter T.   +5 more
core  

Serum Ferritin as a Predictor of Hospital Mortality in Critically Ill COVID-19 Patients

COVID
Serum ferritin levels increase in severe COVID-19 patients. However, few data correlating the sensitivity and specificity of ferritin levels and mortality prediction in COVID-19 exist. The current study aims to investigate the sensitivity and specificity
Ferhat Soykan, Demet Bolukbasi, Erol Toy, Nazan Has Selmi, Asiye Yavuz, Behiye Deniz Kosovali, Nevzat Mehmet Mutlu, Aliye Bastug, Derya Gokcinar, Belgin Akan, Seval Izdes   +10 more
doaj   +1 more source

The IL‐10/IL‐6 Ratio and the Risk Score: Two Cytokines‐Based Predictors for Malignancy‐Associated Hemophagocytic Lymphohistiocytosis in Adults (M‐HLHa)

American Journal of Hematology, EarlyView.
ABSTRACT The predictive value of cytokines (CK) for malignancy‐associated adult hemophagocytic lymphohistiocytosis (M‐HLHa) remains uncertain. We evaluated a cytokine‐based Risk Score (RS) and the IL‐10/IL‐6 Ratio to predict M‐HLHa. Adult patients (n = 112) from the French HLH cohort (NCT02113917) with complete data for nine key HLH related CK measured
Coralie Bloch, Stephanie Chhun, Nanthara Sritharan, Marine Gil, Raphael Lhote, Marouane Boubaya, Olivier Lambotte, David Launay, Claire Larroche, Estibaliz Lazaro, Francois Liffermann, Marc Michel, Jean‐Marie Michot, Pierre Morel, Louis Terriou, Geoffrey Urbansk, Jean‐Francois Viallard, Morgane Cheminant, Felipe Suarez, Yves Lepelletier, Geneviève de Saint Basile, Olivier Hermine, the French HLH Study Group, Coralie Bloch, Jean Philippe Jais, Francois Liffermann, Pierre Morel, Morgane Cheminant, Felipe Suarez, Olivier Hermine, Fabrice Bonnet, Pascal Godemer, Damaj Gandhi, Olivier Fain, Olivier Lambotte, David Launay, Louis Terriou, Claire Larroche, Estibaliz Lazaro, Jean‐Francois Viallard, Francois Liffermann, Olivier Lortholary, Marc Michel, Jean‐Marie Michot, Pierre Morel, Frederic Pene, Antoinette Perlat, Geoffrey Urbanski   +47 more
wiley   +1 more source

Oxidative stress and cell death in cells expressing L-ferritin variants causing neuroferritinopathy

Neurobiology of Disease, 2010
Neuroferritinopathies are dominantly inherited movement disorders associated with nucleotide insertions in the L-ferritin gene that modify the protein's C-terminus.
Anna Cozzi, Elisabetta Rovelli, Grazia Frizzale, Alessandro Campanella, Mario Amendola, Paolo Arosio, Sonia Levi   +6 more
doaj   +1 more source

Iron Oxidation and Core Formation in Recombinant Heteropolymeric Human Ferritins [PDF]

, 2017
In animals, the iron storage and detoxification protein, ferritin, is composed of two functionally and genetically distinct subunit types, H (heavy) and L (light), which co-assemble in various ratios with tissue specific distributions to form shell ...
Poli, Maura, Santambrogio, Paolo, Paolo Santambrogio, Maura Poli, Paolo Arosio, Bou-Abdallah, Fadi, Matthew Mehlenbacher, Arosio, Paolo, Levi, Sonia, Chasteen, N. Dennis, Mehlenbacher, Matthew, N. Dennis Chasteen, Sonia Levi, Fadi Bou-Abdallah   +13 more
core   +1 more source

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

Characterization of the H and L Subunit Ratios of Ferritins by SDS Capillary Gel Electrophoresis

, 2002
Sodium dodecyl sulfate–capillary gel electrophoresis (SDS–CGE) was used to characterize the H- and L-subunit ratios of several mammalian ferritins and one bacterioferritin. Traditionally, SDS–PAGE has been used to characterize the H- and L-subunit ratios
Zang, Jia, Laue, Thomas M., Chasteen, N. Dennis, Grady, John K., Arosio, Paolo   +4 more
core   +1 more source