Results 91 to 100 of about 147,915 (338)
Acta Pharmaceutica Sinica B, 2022 Herein, we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy (DCM) by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model. Advanced glycation end-products (AGEs), an important
Xiang Wang +11 more
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Advanced Materials, EarlyView.This review summarizes recent advances in metal‐based nanomaterials (MBNs) as multifunctional platforms for next‐generation diagnostics and nanodynamic therapies (NDTs), highlighting their structural tunability, diverse therapeutic modalities, and broad biomedical applications in oncology and infectious disease control.
Qihang Ding +11 more
wiley +1 more source
Cell Death and DiseaseFerroptosis, a novel form of regulated cell death induced by the excessive accumulation of lipid peroxidation products, plays a pivotal role in the suppression of tumorigenesis.
Ru Deng +11 more
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Recent progress of ferroptosis in cancers and drug discovery
Asian Journal of Pharmaceutical SciencesFerroptosis is a nonapoptotic form of cell death characterized by iron dependence and lipid peroxidation. Ferroptosis is involved in a range of pathological processes, such as cancer.
Xiang Wang +9 more
doaj +1 more source
Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3 [PDF]
, 2017 学位記番号 ...
Shintoku, Ryosuke +2 more
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NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
Advanced Science, EarlyView.NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source
Ferroptosis in Cardiovascular Disease: Basic Mechanisms and Implications for Cardiovascular Disease
Journal of Mazandaran University of Medical Sciences, 2021 Ferroptosis is a new type of programmed cell death that plays an important role in various cardiovascular diseases, such as myocardial infarction, reperfusion injury, and heart failure.
Soghra Farzipour +4 more
doaj
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells [PDF]
, 2018 Fatty acid uptake and metabolism are often dysregulated in cancer cells. Fatty acid activation is a critical step that allows these biomolecules to enter cellular metabolic pathways such as mitochondrial β-oxidation for ATP generation or the lipogenic ...
Hall, A +6 more
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Advanced Science, EarlyView.BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan +13 more
wiley +1 more source
CONTRASTING EFFECTS OF AN MDM2 FUNCTIONAL POLYMORPHISM ON TUMOR PHENOTYPES [PDF]
, 2017 Cancer predisposition by the cooperation of genetic variants, such as single nucleotide polymorphisms (SNPs), may be of much greater significance to public health than previously appreciated.
Ortiz, Guadalupe J, IV
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