Results 111 to 120 of about 109,999 (379)

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Ferroptosis and Brain Injury [PDF]

Developmental Neuroscience, 2018
Ferroptosis is a nonapoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid reactive oxygen species. Small-molecule screening and subsequent optimization have yielded potent and specific activators and inhibitors of this process.
Leslie Magtanong, Scott J. Dixon
openaire   +2 more sources

Role and mechanism of ferroptosis in neurological diseases

Molecular Metabolism, 2022
Background: Ferroptosis, as a new form of cell death, is different from other cell deaths such as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of several diseases, including cancers, cardiovascular diseases, nervous ...
Mengmeng Ou, Ying Jiang, Yingying Ji, Qin Zhou, Zhiqiang Du, Haohao Zhu, Zhenhe Zhou   +6 more
doaj  

GPX4-independent ferroptosis—a new strategy in disease’s therapy

Cell Death Discovery, 2022
Ferroptosis is a form of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation, and earlier studies identified glutathione peroxidase 4 (GPX4) as an essential regulator of this process.
Tianyu Ma, Jingtong Du, Yufeng Zhang, Yuyao Wang, Bingxuan Wang, Tianhong Zhang   +5 more
doaj   +1 more source

Ferroptosis Detection: From Approaches to Applications.

Angewandte Chemie, 2023
Understanding the molecular machinery regulating ferroptosis and leveraging this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, and prognosis.
Fantian Zeng, Sureya Nijiati, Longguang Tang, Jinmin Ye, Zijian Zhou, Xiaoyuan Chen   +5 more
semanticscholar   +1 more source

Redox-dependent gating of VDAC by mitoNEET. [PDF]

, 2019
MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human maladies including diabetes, cancer, neurodegeneration, and Parkinson's ...
Bai, Fang, Jennings, Patricia A, Lipper, Colin H, Mittler, Ron, Nechushtai, Rachel, Onuchic, José N, Roy, Susmita, Sohn, Yang-Sung, Stofleth, Jason T   +8 more
core  

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

NFE2L1-mediated proteasome function protects from ferroptosis

Molecular Metabolism, 2022
Objective: Ferroptosis continues to emerge as a novel modality of cell death with important therapeutic implications for a variety of diseases, most notably cancer and degenerative diseases.
Stefan Kotschi, Anna Jung, Nienke Willemsen, Anahita Ofoghi, Bettina Proneth, Marcus Conrad, Alexander Bartelt   +6 more
doaj  

Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer

Journal of experimental & clinical cancer research : CR, 2023
Introduction Cuproptosis and ferroptosis are the two newly defined metal-related regulated cell death. However, the crosstalk between cuproptosis and ferroptosis is obscure.
Weikai Wang, Kaizhong Lu, Xin Jiang, Qi Wei, Liyuan Zhu, Xian Wang, Hongchuan Jin, Lifeng Feng   +7 more
semanticscholar   +1 more source