Results 161 to 170 of about 109,999 (379)

Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis

Ecotoxicology and Environmental Safety, 2022
Cadmium (Cd) is a type of high-risk heavy metal that can damage organs such as the liver, but its mechanism is not yet clear. Ferroptosis is a newly discovered mode of regulatory cell death. We explored whether ferroptosis is involved in Cd-induced liver
Zhaoqi He, Peng Shen, Lianjun Feng, Haoyang Hao, Yuhong He, Guyue Fan, Zhuoyu Liu, Kun Zhu, Yiqi Wang, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu, Jiacheng Wu   +12 more
doaj  

Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases

Science Advances
Ferroptosis is a form of iron-dependent, lipid peroxidation–driven regulatory cell death that has been implicated in the pathogenesis of multiple diseases, including organ injury, ischemia/reperfusion, and neurodegenerative diseases.
Qian Huang, Yi Ru, Yingli Luo, Xianyu Luo, Didi Liu, Yinchu Ma, Xinru Zhou, Maoyuan Linghu, Wenjing Xu, Fei Gao, Yi Huang   +10 more
semanticscholar   +1 more source

Autophagy in DNA Damage Response [PDF]

, 2015
DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation ...
Elzbieta Pawlowska, Janusz Blasiak, Jolanta Bialkowska-Warzecha, Kai Kaarniranta, Piotr Czarny   +4 more
core   +2 more sources

Organic AIE Nanoradiosensitizer Potentiates X‐Ray Triggered Continuous Reactive Oxygen Species Generation for Potent Cancer Radioimmunotherapy

Advanced Materials, EarlyView.
Herein, a glutathione‐responsive system (named THN) is prepared for X‐ray‐triggered sustained ROS generation for efficient antitumor immunotherapy. The double‐promoting ROS generation of THN induced massive immunogenic cancer cell death and polarized M2 macrophages into the M1 phenotype for enhanced antitumor immunotherapy.
Qingyong Xu, Minmin Zhang, Qinqin Huang, Song Gao, Sitong Chu, Qi Li, Wanyao Chen, Xinglong Zhang, Tianfu Zhang, Ben Zhong Tang, Shipeng Ning   +10 more
wiley   +1 more source

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Cell, 2022
B. Stockwell
semanticscholar   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Ferroptosis: Frenemy of Radiotherapy

International Journal of Molecular Sciences
Recently, it was established that ferroptosis, a type of iron-dependent regulated cell death, plays a prominent role in radiotherapy-triggered cell death. Accordingly, ferroptosis inducers attracted a lot of interest as potential radio-synergizing drugs, ultimately enhancing radioresponses and patient outcomes.
Lisa Kerkhove, Febe Geirnaert, Inès Dufait, Mark De Ridder   +3 more
openaire   +3 more sources

Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice

Journal of Translational Medicine
Background Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases. The molecular mechanisms by which HFpEF leads to impaired diastolic function of the heart have not been clarified, nor have the drugs
Yixiao Xiong, Xin Liu, Ling Jiang, Tao Hao, Yanyan Wang, Tao Li   +5 more
doaj   +1 more source

Immunometabolism of ferroptosis in the tumor microenvironment

Frontiers in Oncology
Ferroptosis is an iron-dependent form of cell death that results from excess lipid peroxidation in cellular membranes. Within the last decade, physiological and pathological roles for ferroptosis have been uncovered in autoimmune diseases, inflammatory ...
Gian Luca Lupica-Tondo, Emily N. Arner, Denis A. Mogilenko, Kelsey Voss, Kelsey Voss   +4 more
doaj   +1 more source

Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer

Nature Communications
Targeting ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal overload of lipid peroxides, in cancer therapy is impeded by our limited understanding of the intersection of tumour’s metabolic feature and ferroptosis ...
Guoshu Bi, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Yiwei Huang, T. Lu, Huan Zhang, Xing Jin, Zhencong Chen, Mengnan Zhao, Hong Fan, Qun Wang, Boyi Gan, C. Zhan   +13 more
semanticscholar   +1 more source