Results 171 to 180 of about 147,915 (338)

Piezo1 Upregulation in Monocyte‐Derived Macrophages Impairs Post‐Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis

Advanced Science, EarlyView.
This study reports early Piezo1 activation in bone marrow monocyte‐derived macrophages (MoMs) during myocardial infarction (MI), which governs the fate and function of recruited macrophages. The recruited MoMs with increased Piezo1 expression exhibit increased ferroptosis and defective efferocytosis, delayed clearance of dead cells and resolution of ...
Lu Peng, Yunlong Xia, Huishou Zhao, Yongzhen Guo, Xiaoming Xu, Xue Han, Shiyue Wang, Fengyue Ding, Quanchi Liu, Congye Li, Yuan He, Zhaoyi Luo, Qiaojuan Wang, Xing Zhang, Feng Gao, Yajing Wang, Yulin Li, Shengpeng Wang, Ling Tao, Wenjun Yan   +19 more
wiley   +1 more source

Exogenous dihomo-γ-linolenic acid triggers ferroptosis via ACSL4-mediated lipid metabolic reprogramming in acute myeloid leukemia cells

Translational Oncology
Ferroptosis is a novel type of programmed cell death caused by excessive iron-dependent lipid peroxidation. According to various studies, there may be a link between ferroptosis and lipid metabolism.
Xiandong Jiang, Yingying Huang, Xiaoying Hong, Wei Wu, Yanfeng Lin, Liping Lin, Yan Xue, Donghong Lin   +7 more
doaj   +1 more source

A Transmembrane Protein WAI‐B2 Confers Multiple Disease Resistance in Wheat by Activating Autoimmunity

Advanced Science, EarlyView.
Wheat production is under threat from multiple diseases. This study clones the wheat autoimmunity gene WAI‐B2 from an EMS‐induced mutant that encodes a distinct transmembrane protein conferring resistance to wheat rusts and powdery mildew ‐ two major diseases affecting wheat crops.
Wenling Li, Yongxing Chen, Lei Dong, Guanghao Guo, Huaizhi Zhang, Tao Shen, Gaojie Wang, Lingli Dong, Ping Lu, Miaomiao Li, Dan Qiu, Keyu Zhu, Beibei Li, Yikun Hou, Xuejia Cui, Baoge Huang, Fugang Yang, Hongkui Fu, Delin Li, Zhan Li, Jinghuang Hu, Yunfeng Qu, Huanhuan Lou, Shisheng Chen, Zaifeng Li, Ling Kang, Wuyun Yang, Chengguo Yuan, Hongjie Li, Yusheng Zhao, Zhiyong Liu, Haiyan Jia, Qiuhong Wu   +32 more
wiley   +1 more source

SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait. [PDF]

, 2019
de novo fatty acid biosynthesis (DNFA) is a hallmark adaptation of many cancers that supports survival, proliferation, and metastasis. Here we elucidate previously unexplored aspects of transcription regulation and clinical relevance of DNFA in cancers ...
Näär, Anders M, Wu, Su
core  

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.

Nature Chemical Biology, 2017
S. Doll, B. Proneth, Y. Tyurina, Elena Panzilius, Sho Kobayashi, Irina Ingold, M. Irmler, J. Beckers, M. Aichler, A. Walch, H. Prokisch, D. Trümbach, G. Mao, F. Qu, H. Bayır, J. Füllekrug, C. Scheel, W. Wurst, Joel A. Schick, V. Kagan, J. Angeli, M. Conrad   +21 more
semanticscholar   +1 more source

Targeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer

Nature Communications
Therapeutic resistance represents a bottleneck to treatment in advanced gastric cancer (GC). Ferroptosis is an iron-dependent form of non-apoptotic cell death and is associated with anti-cancer therapeutic efficacy. Further investigations are required to
Hui Yang, Qingqing Li, Xingxing Chen, Mingzhe Weng, Yakai Huang, Qiwen Chen, Xiaocen Liu, Haoyu Huang, Yanhuizhi Feng, Hanyu Zhou, Mengying Zhang, W. Pei, Xueqin Li, Qingsheng Fu, Liangyu Zhu, Yingying Wang, Xiang Kong, Kun Lv, Yan Zhang, Yangbai Sun, M. Ma   +20 more
semanticscholar   +1 more source

Ferroptosis spreads to neighboring cells via plasma membrane contacts [PDF]

Bernhard F. Roeck, Sara Lotfipour Nasudivar, Michael R. H. Vorndran, Lena Schueller, Fatma Isil Yapici, Matthias Rübsam, Silvia von Karstedt, Carien M. Niessen, Ana J. García‐Sáez   +8 more
openalex   +1 more source

Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy

, 2022
Yan Fang, Dajun Fang
openalex   +1 more source

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis [PDF]

, 2021
Lei Feng, Kaikai Zhao, Liangchao Sun, Xiaoyang Yin, Junpeng Zhang, Conghe Liu, Baosheng Li   +6 more
openalex   +1 more source