Results 171 to 180 of about 109,999 (379)
Characterizing Ferroptosis in the Model Invertebrate Hydra Vulgaris [PDF]
, 2022 Ferroptosis is a form of regulated cell death distinct from apoptosis. It occurs in diverse animals and in plants, but has not been documented in Hydra vulgaris, a cnidarian species used for studies of stem cell biology and regeneration.
Ott, Darci
core +1 more source
Advanced Science, EarlyView.Predicting immune responses to treatments, including nanomedicines, with high throughput test is challenging due to the immunoreactome's complexity and plasticity. A predictive screening platform integrating pathway activation and gene profiling in macrophages has been developed as a versatile tool for designing effective immunotherapies.
Sonia Becharef +12 more
wiley +1 more source
Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis
Oxidative Medicine and Cellular Longevity, 2019 Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental and conserved mechanism is based on an excess of ROS which attacks biomembranes, propagates ...
L. Su +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang +8 more
wiley +1 more source
Acta Pharmaceutica Sinica B, 2022 Herein, we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy (DCM) by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model. Advanced glycation end-products (AGEs), an important
Xiang Wang +11 more
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ケミカルスクリーニングを駆使したオートファジー制御化合物の探索と、抗がん剤の薬効機序解析手法の確立 [PDF]
, 2018 筑波大学 (University of Tsukuba ...
Sano Osamu, 佐野 修
core +1 more source
Advanced Science, EarlyView.Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou +16 more
wiley +1 more source
Targeting ferroptosis as a vulnerability in cancer
Nature Reviews. Cancer, 2022 Guang Lei, Zhuang Li, B. Gan
semanticscholar +1 more source
Advanced Science, EarlyView.Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song +9 more
wiley +1 more source
Ferroptosis in Cardiovascular Disease: Basic Mechanisms and Implications for Cardiovascular Disease
Journal of Mazandaran University of Medical Sciences, 2021 Ferroptosis is a new type of programmed cell death that plays an important role in various cardiovascular diseases, such as myocardial infarction, reperfusion injury, and heart failure.
Soghra Farzipour +4 more
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