Results 171 to 180 of about 115,871 (339)

Targeting Methylglyoxal Metabolism to Enhance Ferroptosis Sensitivity in Tumor Therapy

Advanced Science, EarlyView.
This study reveals how blocking a detox enzyme called GLO1 increases the buildup of a toxic molecule, methylglyoxal (MGO), which triggers cancer cell death by ferroptosis. A protein called PJA1 drives this process. Targeting the PJA1–GLO1 pathway boosts the effectiveness of ferroptosis‐inducing treatments in tumors, offering a promising approach for ...
Xinyue Zhang, Leng Han, Zimu Wang, Hanghui Yu, Jiao Liu, Rui Kang, Daolin Tang, Zhengjia Liu, Xianlong Du, Enyong Dai   +9 more
wiley   +1 more source

NSC‐34 motor neuron‐like cells are sensitized to ferroptosis upon differentiation [PDF]

, 2018
Alejandra M. Martinez, Jovan Mirkovic, Zofia Stanisz, Fahmida S. Patwari, Wan Seok Yang   +4 more
openalex   +1 more source

Inhibition of tubular epithelial cells ferroptosis alleviates renal interstitial fibrosis by reducing lipid hydroperoxides and TGF-β/Smad signaling

Cell Communication and Signaling
Background Ferroptosis is a non-apoptotic form of regulated cell death that involves an imbalance in the homeostasis of two elements: iron and lipid hydroperoxides.
Yuting Chen, Yue Dai, Yi Huang, Le Zhang, Cuntai Zhang, Hongyu Gao, Qi Yan   +6 more
doaj   +1 more source

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

, 2014
Scott J. Dixon, Darpan N. Patel, Matthew Welsch, Rachid Skouta, Eric D. Lee, Miki Hayano, Ajit G. Thomas, Caroline E. Gleason, Nicholas P. Tatonetti, Barbara S. Slusher, Brent R. Stockwell   +10 more
openalex   +1 more source

SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait. [PDF]

, 2019
de novo fatty acid biosynthesis (DNFA) is a hallmark adaptation of many cancers that supports survival, proliferation, and metastasis. Here we elucidate previously unexplored aspects of transcription regulation and clinical relevance of DNFA in cancers ...
Näär, Anders M, Wu, Su
core  

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

Advanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez, Maria Virginia Giolito, Sultan Al‐Siyabi, Kristian Serafimov, Florine Laloux, Emeline Dierge, Léo Aubert, Céline Guilbaud, Selena Kaye, Paula Varon, Dorothée Marchand, Hanne Vlieghe, Emmanuel Hermans, Caroline Bouzin, Davide Brusa, Christiani Andrade Amorim, Barabara Pachikian, Yvan Larondelle, Cyril Corbet, Chantal Dessy, Olivier Feron   +20 more
wiley   +1 more source

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

, 2015
Liuji Chen, William S. Hambright, Ren Na, Qitao Ran   +3 more
openalex   +1 more source

A ferroptosis–based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis [PDF]

, 2019
David Devos, Caroline Moreau, Maéva Kyheng, Guillaume Garçon, Anne‐Sophie Rolland, Hélène Blasco, Patrick Gelé, Timothée Lenglet, Charlotte Veyrat‐Durebex, Philippe Corcia, Mary Dutheil, Peter Bede, Andreas Jeromin, Patrick Oeckl, Markus Otto, Vincent Meininger, Véronique Danel-Brunaud, Jean-Christophe Devedjian, James A. Duce, Pierre Pradat   +19 more
openalex   +1 more source

Deoxynivalenol Exposure Leads to Abnormal Renal Tubular Autophagy Flow

Advanced Science, EarlyView.
DON exposure disrupts the initiation of renal autophagy by inhibiting the formation of autophagosomes, thereby impairing mitochondrial degradation. Damaged mitochondria increase oxidative stress, reduce ferroptosis resistance, and cause lysosomal Fe2⁺ accumulation, further disrupting autophagy.
Hao Chen, Xintong Zhou, Jun Ma
wiley   +1 more source

Immunometabolism of ferroptosis in the tumor microenvironment

Frontiers in Oncology
Ferroptosis is an iron-dependent form of cell death that results from excess lipid peroxidation in cellular membranes. Within the last decade, physiological and pathological roles for ferroptosis have been uncovered in autoimmune diseases, inflammatory ...
Gian Luca Lupica-Tondo, Emily N. Arner, Denis A. Mogilenko, Kelsey Voss, Kelsey Voss   +4 more
doaj   +1 more source