Results 181 to 190 of about 72,927 (343)

Polyamine-Mediated Ferroptosis Amplification Acts as a Targetable Vulnerability in Cancer [PDF]

Targeting ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal overload of lipid peroxides, in cancer therapy is impeded by our limited understanding of the intersection of tumour’s metabolic feature and ferroptosis ...
Bi, Guoshu, Bian, Yunyi, Chen, Zhencong, Fan, Hong, Gan, Boyi, Huang, Yiwei, Jin, Xing, Liang, Jiaqi, Lu, Tao, Shan, Guangyao, Wang, Qun, Zhan, Cheng, Zhang, Huan, Zhao, Mengnan   +13 more
core   +1 more source

Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option? [PDF]

Ferroptosis is a form of iron-dependent regulated cell death caused by the accumulation of lipid peroxides. In this review, we summarize research on the impact of ferroptosis on disease models and isolated cells in various types of arthritis.
Amsler, Jennifer, Bieri, Shania, Möller, Burkhard   +2 more
core   +1 more source

Turning on the Heat by Cocrystal Engineering: The Rise of Organic Charge Transfer Photothermal Cocrystals as an Emerging Therapeutic Frontier in Biomedical Application

Aggregate, EarlyView.
This review summarizes recent developments in the design of photothermal charge transfer cocrystals for antibacterial therapy, cancer eradication, and bone regeneration, highlighting the design motivations and chemical principles of the strategies. It offers deep insights into the future development of advanced photothermal cocrystals for targeted ...
Arshad Khan, Rabia Usman, Shuo Xiang, Yasinalli Tamboli, Muhammad Umair, Awatef M. Alshehri, Ibraheem Bushnak, Yan Deng, Nongyue He   +8 more
wiley   +1 more source

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

, 2014
Scott J. Dixon, Darpan N. Patel, Matthew Welsch, Rachid Skouta, Eric D. Lee, Miki Hayano, Ajit G. Thomas, Caroline E. Gleason, Nicholas P. Tatonetti, Barbara S. Slusher, Brent R. Stockwell   +10 more
openalex   +1 more source

FSP1 is a glutathione-independent ferroptosis suppressor [PDF]

, 2019
Sebastian Doll, Florêncio Porto Freitas, Ron Shah, Maceler Aldrovandi, Milene Costa da Silva, Irina Ingold, Andrea Goya Grocin, Thamara Nishida Xavier da Silva, Elena Panzilius, Christina Scheel, André Mourão, Katalin Buday, Mami Sato, Jonas Wanninger, Thibaut Vignane, Vaishnavi Mohana, Markus Rehberg, Andrew Flatley, Aloys Schepers, Andreas Kurz, Daniel A. White, Markus Sauer, Michael Sattler, Edward W. Tate, Werner Schmitz, Almut Schulze, Valerie B. O’Donnell, Bettina Proneth, Grzegorz M. Popowicz, Derek A. Pratt, José Pedro Friedmann Angeli, Marcus Conrad   +31 more
openalex   +1 more source

Construction of Active Sites‐Accessible Au8 Clusters for Intensive Tumor Pyroptosis

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Ethynylferrocene (EFc) was utilized to engineer molecular‐like gold nanoclusters (NCs) with accessibly catalytic centers, resulting in NCs exhibiting excellent peroxidase‐like activity and the ability to radiosensitize, leading to the production of intracellular oxidative stress and activation of pyroptosis.
Qiu‐Xu Zang, Wei‐Tong Chen, Wenjing Zhang, Zhao‐Yang Wang, Xi‐Yan Dong, Runping Han, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

CircUCK2 regulates HECTD1‐mediated endothelial‐mesenchymal transition inhibition by interacting with FUS and protects the blood–brain barrier in ischemic stroke

The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 1, Page 40-51, January 2023., 2023
Abstract Ischemic stroke (IS) has become a cerebrovascular disease of widespread concern. Overexpression of circUCK2 alleviates neuronal damage in IS. However, the specific regulatory mechanisms of circUCK2 are not fully understood. In this study, we found that circUCK2 and HECT domain E3 ubiquitin ligase 1 (HECTD1) were downregulated in IS models in ...
Jun‐Hong Zhuang, Huan‐Xiong Chen, Ning Gao, Rong‐Dao Sun, Cheng‐Ye Xiao, De‐Hua Zeng, Zheng‐Tao Yu, Jun Peng, Ying Xia   +8 more
wiley   +1 more source

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

, 2015
Liuji Chen, William S. Hambright, Ren Na, Qitao Ran   +3 more
openalex   +1 more source

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling [PDF]

, 2019
Jiao Wu, Alexander M. Minikes, Minghui Gao, Huijie Bian, Yong Li, Brent R. Stockwell, Zhi‐Nan Chen, Xuejun Jiang   +7 more
openalex   +1 more source

Hydrogel‐Based Smart Materials for Wound Healing and Sensing

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The graphical abstract illustrates the role of hydrogel‐based flexible materials in advancing biomedical applications, including wound healing, point‐of‐care diagnostics, smart patches, and wearable devices. Hydrogels are particularly promising in modern wound care due to their high‐water content, flexibility, and biocompatibility.
Thi Kim Ngan Duong, Thi Thuy Truong, Thi Nhat Linh Phan, Thi Xuan Nguyen, Vu Hoang Minh Doan, Truong Tien Vo, Jaeyeop Choi, Umapada Pal, Prodyut Dhar, Byeongil Lee, Junghwan Oh, Sudip Mondal   +11 more
wiley   +1 more source