Results 311 to 320 of about 109,999 (379)

Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells

, 2020
Marcos A. Perez, Leslie Magtanong, Scott J. Dixon, Jennifer L. Watts   +3 more
openalex   +1 more source

ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling

Advanced Science, EarlyView.
In this study, ferroptosis in colorectal cancer cells is induced by FK866 through the NAD⁺/STAT3/GPX4 pathway. To minimize systemic toxicity, a reactive oxygen species (ROS)‐responsive hydrogel is developed to co‐deliver FK866 and C188‐9, resulting in synergistic and localized antitumor effects.
Chenyang Ye, Mi Mi, Saimeng Shi, Lina Qi, Shanshan Weng, Lu Wang, Yier Lu, Chao Chen, Yinuo Tan, Mengyuan Yang, Cheng Guo, Rui Bai, Xuefeng Fang, Ji Wang, Ying Yuan   +14 more
wiley   +1 more source

Role of non-coding RNA-regulated ferroptosis in colorectal cancer. [PDF]

Cell Death Discov
Zhao YP, Liu JL, Wang S, Li X.
europepmc   +1 more source

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

, 2020
Nobuaki Takahashi, Patricia Cho, Laura M. Selfors, Hendrik J. Kuiken, Roma Kaul, Takuro Fujiwara, Isaac S. Harris, Tian Zhang, Steven P. Gygi, Joan S. Brugge   +9 more
openalex   +1 more source

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

Advanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo, Xiaoli Jin, Lan Huang, Dejia Zeng, Nan Zhang, Shiyu Tang, Shu Luo, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Shufang Liang   +10 more
wiley   +1 more source

Ferroptosis: a novel pharmacological mechanism against multiple myeloma. [PDF]

Front Pharmacol
Shi J, Lu Y, Wei W, Ma G, Li C, Li L, Wang Y, Wang Y, Xu R, Cui S.   +9 more
europepmc   +1 more source

Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation

Advanced Science, EarlyView.
PANoptosis activation is an effective therapeutic target during mastitis progression, and Gasdermin D activation is key factor contributing to blood milk barrier damage during mastitis, while cyanidin 3‐O‐galactoside can inhibit these targets to exert a protective effect. Therefore, the extraction of key active ingredients from plants for the treatment
Rui Feng, Lin Guo, Fan Wang, Qian Zhang, Guoyan Wang, Hefei Huang, Wei Du, Hong An, Yue Yang, Henghui Miao, Peng Zheng, Tingting Chu, Dengke Zhang, Xiaoxue Yan, Xiaoyu Mi, Qian Ma, Weilin Gao, Yushan Li, Song Li, Yong Zhang, Zhenliang Zhu, Yu Wang, Jun Liu, Xu Liu   +23 more
wiley   +1 more source

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update. [PDF]

Front Aging Neurosci
Zhou B, Li J, Wu A, Wang X, Cheng L, Yang G, Gao D, Zhu C.   +7 more
europepmc   +1 more source

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.

Nature Chemical Biology, 2017
V. Kagan, G. Mao, F. Qu, J. Angeli, S. Doll, C. S. Croix, H. Dar, B. Liu, V. Tyurin, V. Ritov, A. Kapralov, A. Amoscato, Jianfei Jiang, T. Anthonymuthu, D. Mohammadyani, Qin Yang, B. Proneth, J. Klein-Seetharaman, Simon C Watkins, I. Bahar, J. Greenberger, R. Mallampalli, B. Stockwell, Y. Tyurina, M. Conrad, H. Bayır   +25 more
semanticscholar   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source