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Ferroptosis: Concepts and Definitions
2021Ferroptosis is a newly discovered form of cell death that is rapidly becoming associated to a variety of diseases and explaining their pathological mechanisms. This book addresses new emerging topics in the field of ferroptosis, with special attention to diseases more recently explained through ferroptotic mechanisms, including infectious diseases and ...
Andrés F, Flórez, Hamed, Alborzinia
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Ferroptosis in Neurological Disease
The Neuroscientist, 2022Iron accumulation in the CNS occurs in many neurological disorders. It can contribute to neuropathology as iron is a redox-active metal that can generate free radicals. The reasons for the iron buildup in these conditions are varied and depend on which aspects of iron influx, efflux, or sequestration that help maintain iron homeostasis are ...
Samuel David +3 more
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Ferroptosis and Cancer Immunotherapy
Current Molecular Medicine, 2023Abstract: Traditional treatment strategies for cancer are unsatisfactory. As a nonapoptotic cell death process and owning to the characteristics of iron-dependent lipid peroxide accumulation, ferroptosis has become a new target of tumor treatment. Numerous studies have proved that ferroptosis could enhance the immunogenicity of cancer and interact ...
Jumei, Yin +6 more
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Journal of Leukocyte Biology
Abstract Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms.
Yu-Bin Lee +6 more
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Abstract Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms.
Yu-Bin Lee +6 more
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Monitoring autophagy-dependent ferroptosis
2021Ferroptosis is an iron-dependent form of regulated cell death, driven by the accumulation of lipid peroxidation. Autophagy is a lysosome-dependent degradation process that can be used to remove and recover intracellular components, such as dysfunctional proteins and damaged organelles.
Jingbo, Li, Rui, Kang, Daolin, Tang
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Ferroptosis in Cardiovascular Diseases and Ferroptosis-Related Intervention Approaches
Cardiovascular Drugs and TherapyCardiovascular diseases (CVDs) are major public health problems that threaten the lives and health of individuals. The article has reviewed recent progresses about ferroptosis and ferroptosis-related intervention approaches for the treatment of CVDs and provided more references and strategies for targeting ferroptosis to prevent and treat CVDs.A ...
Xianpeng, Zhou +9 more
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Ferroptosis and kidney diseases
International Urology and Nephrology, 2019Ferroptosis is a form of iron-dependent, non-apoptotic regulated cell death, which is characterized by the accumulation of lipid hydroperoxides to lethal levels. Ferroptosis recently has been shown to have implications in diverse kidney diseases, such as acute kidney injury, polycystic kidney disease and renal cell carcinoma.
Shumei, Tang, Xiangcheng, Xiao
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Ferroptosis in mitochondrial cardiomyopathy
Trends in Cell BiologyFerroptosis is a form of necrotic cell death characterized by iron-dependent lipid peroxidation culminating in membrane rupture. Accumulating evidence links ferroptosis to multiple cardiac diseases and identifies mitochondria as important regulators of ferroptosis.
Ahola, S., Langer, T.
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Ferroptosis contributes to immunosuppression
Frontiers of MedicineAs a novel form of cell death, ferroptosis is mainly regulated by the accumulation of soluble iron ions in the cytoplasm and the production of lipid peroxides and is closely associated with several diseases, including acute kidney injury, ischemic reperfusion injury, neurodegenerative diseases, and cancer. The term "immunosuppression" refers to various
Nina, He +7 more
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